Basic information

Full name
small nuclear ribonucleoprotein U5 subunit 200
Ensembl
ENSG00000144028.15
Summary
Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.5e-24--1.8e-3--7.4e-89.5e-268.2e-29--0.26-
protein3.8e-96-1.1e-141.7e-32-4e-183.2e-351.6e-316.6e-9-0.0750.013

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC10.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC25.425.625.82626.226.426.626.82727.227.427.627.82828.2log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SNRNP200 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETS2.1e-521.8e-97.1e-40.21.5e-72.2e-162.2e-165.2e-44.5e-37.6e-49.1e-10
HALLMARK_G2M_CHECKPOINT1.7e-461.7e-61.2e-30.284.6e-73.6e-122.2e-163.1e-40.0391.1e-41.3e-10
chromosomal instability1.2e-431e-80.0290.0885.7e-72.2e-162.2e-165.3e-48.8e-60.0140.016
HALLMARK_MYC_TARGETS_V29.8e-392.7e-110.220.627.4e-66.1e-52.2e-162.3e-38.1e-55.8e-41.6e-8
xcell: T cell CD4+ Th11.5e-362.8e-160.645.1e-32.7e-81.7e-42.1e-92.6e-30.477.6e-41.3e-9
KINASE-PSP_CDK27e-361.9e-64.4e-33.9e-52.7e-66.1e-61.7e-75.9e-36.2e-52.5e-33.1e-4
HALLMARK_SPERMATOGENESIS5.9e-332.5e-80.180.420.0611.2e-92.2e-169.6e-66.9e-50.0231.2e-3
HALLMARK_DNA_REPAIR7.3e-293.2e-80.0450.471.6e-59.4e-42.2e-160.0730.0681.8e-41.3e-4
Tumor Purity (ABSOLUTE)1.4e-260.140.0530.0296.1e-91.3e-55.7e-140.696.2e-32.1e-32.2e-5
Tumor Purity (WGS)5.3e-25-0.1-6.3e-111.2e-82e-130.27-0.251.2e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SNRNP200

BRCA0.23-0.000.37proteinmRNASCNVmethylationCCRCC0.33-0.01-0.13-0.160.23-0.25proteinmRNASCNVmethylationCOAD0.290.280.20proteinmRNASCNVmethylationGBM0.60-0.19-0.07-0.160.06-0.02proteinmRNASCNVmethylationHNSCC0.44-0.060.33-0.030.51-0.15proteinmRNASCNVmethylationLSCC0.560.030.310.010.46-0.07proteinmRNASCNVmethylationLUAD0.500.020.310.080.53-0.04proteinmRNASCNVmethylationOV0.170.250.29proteinmRNASCNVmethylationPDAC0.170.070.11-0.030.220.06proteinmRNASCNVmethylationUCEC0.430.050.25-0.090.38-0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SNRNP200 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.