Basic information
- Full name
- small nuclear ribonucleoprotein U5 subunit 200
- Ensembl
- ENSG00000144028.15
- Summary
- Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
- Annotation
- Essential genes
Protein product
- ENST00000323853.10 Primary ENSP00000317123.5 (17 phosphosites)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 2.5e-24 | - | -1.8e-3 | - | - | 7.4e-8 | 9.5e-26 | 8.2e-29 | - | -0.26 | - |
protein | 3.8e-96 | - | 1.1e-14 | 1.7e-32 | - | 4e-18 | 3.2e-35 | 1.6e-31 | 6.6e-9 | -0.075 | 0.013 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SNRNP200 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_E2F_TARGETS | 2.1e-52 | 1.8e-9 | 7.1e-4 | 0.2 | 1.5e-7 | 2.2e-16 | 2.2e-16 | 5.2e-4 | 4.5e-3 | 7.6e-4 | 9.1e-10 | |
HALLMARK_G2M_CHECKPOINT | 1.7e-46 | 1.7e-6 | 1.2e-3 | 0.28 | 4.6e-7 | 3.6e-12 | 2.2e-16 | 3.1e-4 | 0.039 | 1.1e-4 | 1.3e-10 | |
chromosomal instability | 1.2e-43 | 1e-8 | 0.029 | 0.088 | 5.7e-7 | 2.2e-16 | 2.2e-16 | 5.3e-4 | 8.8e-6 | 0.014 | 0.016 | |
HALLMARK_MYC_TARGETS_V2 | 9.8e-39 | 2.7e-11 | 0.22 | 0.62 | 7.4e-6 | 6.1e-5 | 2.2e-16 | 2.3e-3 | 8.1e-5 | 5.8e-4 | 1.6e-8 | |
xcell: T cell CD4+ Th1 | 1.5e-36 | 2.8e-16 | 0.64 | 5.1e-3 | 2.7e-8 | 1.7e-4 | 2.1e-9 | 2.6e-3 | 0.47 | 7.6e-4 | 1.3e-9 | |
KINASE-PSP_CDK2 | 7e-36 | 1.9e-6 | 4.4e-3 | 3.9e-5 | 2.7e-6 | 6.1e-6 | 1.7e-7 | 5.9e-3 | 6.2e-5 | 2.5e-3 | 3.1e-4 | |
HALLMARK_SPERMATOGENESIS | 5.9e-33 | 2.5e-8 | 0.18 | 0.42 | 0.061 | 1.2e-9 | 2.2e-16 | 9.6e-6 | 6.9e-5 | 0.023 | 1.2e-3 | |
HALLMARK_DNA_REPAIR | 7.3e-29 | 3.2e-8 | 0.045 | 0.47 | 1.6e-5 | 9.4e-4 | 2.2e-16 | 0.073 | 0.068 | 1.8e-4 | 1.3e-4 | |
Tumor Purity (ABSOLUTE) | 1.4e-26 | 0.14 | 0.053 | 0.029 | 6.1e-9 | 1.3e-5 | 5.7e-14 | 0.69 | 6.2e-3 | 2.1e-3 | 2.2e-5 | |
Tumor Purity (WGS) | 5.3e-25 | - | 0.1 | - | 6.3e-11 | 1.2e-8 | 2e-13 | 0.27 | - | 0.25 | 1.2e-4 |
Cis-association
Associations between omics data of SNRNP200
Trans-association
Associations of the protein abundance of SNRNP200 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.