Basic information

Phenotype

CTNNB1 mutation

Description

Somatic non-synonymous mutation in CTNNB1 compared to samples without a non-synonymous mutation.

Method

Somatic mutations were converted from the genome assembly hg38 to hg19 by CrossMap (version 0.5.3). Unmapped mutations were excluded from downstream analysis. MutSigCV (version 1.41)was applied to the converted somatic mutations to identify significantly mutated genes (q value < 0.01) for each cancer type. Synonymous mutations were not included. The default reference files, background coverage (exome full192), mutation types, and gene covariates, were used in this analysis.

Gene association

Number of significant genes with P-value ≤ 10^-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.

Association of protein abundance of genes

Protein RNA SCNV

		Signed p-values
Gene	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC

* P-values for individual cohorts can be clicked to show the data plots. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with CTNNB1 mutation to WebGestalt.

Phosphosite association

Number of significant genes with P-value ≤ 10^-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.

* P-values for individual cohorts can be clicked to show the data plots.

Gene set enrichment analysis

Submit phosphorylation sites and the common logarithm of the p-values of their association with CTNNB1 mutation to WebGestalt.