Basic information
- Phenotype
- PROGENy: PI3K
- Description
- Score representing the activity of the PI3K pathway. It was calculated using the PROGENy tool on the RNA data (genes with mean FPKM expression >0).
- Source
- https://www.nature.com/articles/s41467-017-02391-6; https://www.sciencedirect.com/science/article/abs/pii/S1874939919302287?via%3Dihub
- Method
- The PROGENy scores were inferred using the R package progeny (V1.10.0) (PMID: 29295995) with default parameters using the RNA expression data (FPKM). Genes with mean expression = 0 in a cohort were removed from the analysis.
- Genes
-
- AEBP1
- AMIGO1
- APOC1
- ARSJ
- ATP6V1G2
- BAAT
- BEGAIN
- C11orf1
- C5orf52
- CA14
- Array
- CAMLG
- CBX7
- CCDC25
- CCDC28A
- CDK5RAP3
- CIR1
- COMMD6
- COQ8A
- CREB3L4
- CREBRF
- CRYL1
- CTDSP1
- CTSF
- Array
- CYTL1
- DERL3
- DHRS12
- DNAL4
- FAXDC2
- FBXO25
- FCGRT
- FCMR
- FHIT
- GAA
- GEMIN8
- Array
- GLI4
- GNPTG
- HSBP1L1
- HSD17B8
- ING4
- INO80C
- INPP5K
- KRTAP19-1
- LRRC23
- MCAM
- MFGE8
- MLANA
- MST1
- MYL5
- NENF
- NR2E1
- Array
- NT5M
- PAEP
- PEX11G
- PMEL
- RGS10
- RPS29
- S100A1
- SLC18A1
- SLC26A4
- SLC27A1
- SMIM19
- SPSB3
- Array
- TBC1D15
- TFDP2
- THNSL2
- TMEM42
- TNNI3
- TPPP
- TRIM63
- Array
- TSNARE1
- TTC12
- TYR
- UBALD2
- VAMP5
- Array
- WDR31
- WDR78
- WIPI2
- YBX2
- ZNF554
- ZSCAN2
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
| Signed p-values | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with PROGENy: PI3K to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
| Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with PROGENy: PI3K to WebGestalt.