Basic information
- Full name
- ATP binding cassette subfamily F member 3
- Ensembl
- ENSG00000161204.11
- Summary
- This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. The protein encoded by this gene displays antiviral effect against flaviviruses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Protein product
- ENST00000429586.6 Primary ENSP00000411471.2 (11 phosphosites)
- ENST00000292808.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 2.1e-6 | - | -1.9e-21 | - | - | 9.1e-5 | 1.4e-29 | 2.9e-7 | - | -0.13 | - |
protein | 3e-35 | - | -2.1e-8 | 9.8e-19 | - | 1e-8 | 8.5e-35 | 2.2e-24 | 4.3e-3 | -2.4e-3 | 1.6e-4 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ABCF3 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_MYC_TARGETS_V2 | 1.8e-16 | 0.48 | 1.2e-3 | 0.015 | 0.023 | 0.12 | 7.5e-7 | 3.0e-4 | 0.17 | 0.3 | 1.5e-6 | |
HALLMARK_DNA_REPAIR | 3.1e-15 | 0.92 | 1.5e-3 | 0.35 | 6.0e-4 | 0.3 | 2.9e-6 | 4.0e-6 | 0.15 | 0.11 | 9.1e-5 | |
chromosomal instability | 2.5e-14 | 0.039 | 0.12 | 0.66 | 0.27 | 1.7e-4 | 4.4e-8 | 0.43 | 2.5e-3 | 8.6e-3 | 0.001 | |
HALLMARK_E2F_TARGETS | 5.7e-13 | 0.062 | 0.028 | 0.11 | 0.45 | 0.52 | 1.1e-5 | 1.5e-5 | 0.22 | 0.11 | 2.9e-5 | |
KINASE-PSP_CDK2 | 3e-12 | 0.13 | 0.014 | 0.02 | -0.83 | 0.77 | 9.1e-5 | 2.5e-3 | 3.3e-3 | 0.34 | 1.1e-6 | |
HALLMARK_MTORC1_SIGNALING | 3.5e-12 | 0.43 | 0.081 | 0.046 | 0.013 | 0.014 | 5.8e-9 | 1.7e-3 | 0.45 | -0.72 | 1.4e-3 | |
HALLMARK_G2M_CHECKPOINT | 7.2e-12 | 0.035 | 0.1 | 0.2 | 0.58 | 0.12 | 1.4e-4 | 3.6e-5 | 0.27 | 0.2 | 2.5e-5 | |
HALLMARK_MYC_TARGETS_V1 | 2.4e-11 | 0.37 | 1.4e-3 | 0.08 | 0.08 | -0.48 | 1.9e-7 | 3.2e-4 | 0.34 | 0.15 | 2.4e-3 | |
HALLMARK_SPERMATOGENESIS | 5.1e-11 | 0.032 | 0.94 | 0.1 | -0.15 | 5.8e-3 | 2.2e-8 | 0.013 | 3.1e-4 | 0.64 | 5.7e-4 | |
KINASE-PSP_CDK1 | 1e-9 | 0.6 | 0.93 | 8.2e-3 | 0.11 | 0.38 | 4.9e-3 | 0.01 | 0.034 | 0.093 | 1.1e-5 |
Cis-association
Associations between omics data of ABCF3
Trans-association
Associations of the protein abundance of ABCF3 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.