Basic information

Full name
acid phosphatase 1
Ensembl
ENSG00000143727.16
Summary
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
Annotation
Phosphatase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.7e-41-4.2e-10--3.8e-52.2e-237.4e-20-0.55-
protein0.71-8.6e-6-0.19--0.039-3.4e-3-2.2e-80.030.042.2e-5

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC9.51010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2424.52525.52626.52727.528log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer0510152025303540450-5-10-15-20-25-30-35-40-45proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ACP1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PERT-PSP_NOCODAZOLE1.1e-70.440.332.1e-30.30.24.5e-40.0320.910.0780.035
KINASE-PSP_ERK2/MAPK11.7e-6-0.960.0553.7e-37.6e-30.840.30.26-0.988.1e-50.16
KINASE-PSP_mTOR/MTOR1.0e-43.0e-4--0.930.18----5.8e-3
KINASE-PSP_AMPKA1/PRKAA15.4e-4----0.29----6.5e-90.21
chromosomal instability5.9e-40.780.40.15-0.670.329.5e-40.262.1e-30.63-0.81
cibersort: B cell memory6.6e-40.30.0830.290.0440.210.94-0.760.640.0140.33
Tumor Purity (ABSOLUTE)1.1e-30.64.6e-30.092-0.550.510.014-0.493.6e-30.11-0.28
PERT-PSP_EGF1.4e-30.180.150.180.180.97-0.540.49-0.413.4e-60.5
KINASE-PSP_PAK13.1e-3---0.20.37-0.39--0.352.3e-80.2
KINASE-PSP_ERK1/MAPK34.4e-3-0.280.260.0060.020.71-0.990.46-0.415.6e-30.41
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ACP1

BRCA0.390.160.48proteinmRNASCNVmethylationCCRCC0.320.090.100.000.03-0.05proteinmRNASCNVmethylationCOAD0.170.220.45proteinmRNASCNVmethylationGBM0.24-0.040.15-0.000.07-0.01proteinmRNASCNVmethylationHNSCC0.33-0.000.25-0.010.520.02proteinmRNASCNVmethylationLSCC0.730.010.360.030.450.26proteinmRNASCNVmethylationLUAD0.48-0.110.22-0.040.37-0.22proteinmRNASCNVmethylationOV0.540.370.62proteinmRNASCNVmethylationPDAC0.070.01-0.01-0.020.140.13proteinmRNASCNVmethylationUCEC0.270.010.15-0.080.02-0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ACP1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.