Gene: ACP2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
acid phosphatase 2, lysosomal
Ensembl
ENSG00000134575.13
Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Annotation
Phosphatase

Protein product

  • ENST00000672073.1 Primary ENSP00000500291.1 (0 phosphosite)
  • ENST00000256997.9
  • ENST00000672636.2
  • ENST00000533929.7
  • ENST00000527256.7
  • ENST00000529444.7
  • ENST00000672787.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.6e-5--8.9e-6--1.5e-48.2e-35.2e-20--0.055-
protein-0.061--5.5e-160.78-8.7e-70.295.5e-70.025-3.3e-44.5e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC88.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC22.52323.52424.52525.52626.527log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ACP2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Macrophage7e-350.022.2e-161.3e-57.3e-61.3e-62.6e-50.0110.0814.4e-46.2e-3
xcell: Macrophage M17.3e-300.022e-102e-78.4e-62.1e-64.4e-50.0350.0380.085.3e-3
HALLMARK_IL6_JAK_STAT3_SIGNALING2.4e-280.316.8e-77.2e-74.2e-41.6e-42.2e-160.0690.232.2e-30.016
HALLMARK_INFLAMMATORY_RESPONSE9.4e-280.071.2e-43.9e-83.8e-42.7e-54.1e-100.0320.381.4e-40.012
xcell: immune score4.5e-250.485.1e-91.6e-46.4e-63.1e-72.5e-60.160.182.9e-30.02
HALLMARK_COMPLEMENT8.6e-250.112.5e-63.8e-73.7e-59.0e-66.2e-90.220.220.030.034
ESTIMATE: ImmuneScore2.4e-230.321.4e-55.5e-61.4e-41.6e-61.4e-80.240.145.8e-30.058
HALLMARK_ALLOGRAFT_REJECTION1.8e-220.792.7e-61.8e-77.1e-43.6e-61.6e-80.240.140.0160.051
xcell: Macrophage M23.9e-210.342.6e-52.3e-41.5e-41.3e-55.6e-40.040.191.9e-40.022
PROGENy: TNFa6.8e-210.0651.2e-32.9e-41.2e-34.4e-54.4e-80.0360.741.3e-30.012
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ACP2

BRCA0.670.250.31proteinmRNASCNVmethylationCCRCC0.59-0.05-0.19-0.15-0.070.02proteinmRNASCNVmethylationCOAD0.630.210.23proteinmRNASCNVmethylationGBM0.570.050.28-0.100.270.06proteinmRNASCNVmethylationHNSCC0.68-0.250.21-0.160.360.10proteinmRNASCNVmethylationLSCC0.730.060.360.120.380.20proteinmRNASCNVmethylationLUAD0.59-0.020.24-0.180.31-0.07proteinmRNASCNVmethylationOV0.490.190.40proteinmRNASCNVmethylationPDAC0.32-0.05-0.09-0.160.270.13proteinmRNASCNVmethylationUCEC0.530.150.180.110.130.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ACP2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.