Basic information

Full name
activin A receptor type 1C
Ensembl
ENSG00000123612.16
Summary
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Annotation
Protein Kinase Receptor

Protein product

  • ENST00000243349.13 Primary ENSP00000243349.7 (0 phosphosite)
  • ENST00000409680.7
  • ENST00000335450.7
  • ENST00000348328.9
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.4e-3--4.3e-22--4.8e-91.1e-266.8e-3--1.0e-4-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer0123456780-1-2-3-4-5-6-7-8proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ACVR1C with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: B cell plasma-----------
cibersort: T cell CD4+ memory resting-----------
cibersort: T cell regulatory (Tregs)-----------
cibersort: NK cell activated-----------
cibersort: Macrophage M1-----------
cibersort: Myeloid dendritic cell activated-----------
cibersort: Eosinophil-----------
xcell: B cell-----------
xcell: T cell CD8+ effector memory-----------
xcell: Common myeloid progenitor-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ACVR1C

BRCA0.19proteinmRNASCNVmethylationCCRCC0.260.10-0.06proteinmRNASCNVmethylationCOAD0.38proteinmRNASCNVmethylationGBM-0.040.17-0.01proteinmRNASCNVmethylationHNSCC-0.070.070.12proteinmRNASCNVmethylationLSCC-0.030.20-0.06proteinmRNASCNVmethylationLUAD0.03-0.03-0.03proteinmRNASCNVmethylationOV0.00proteinmRNASCNVmethylationPDAC-0.070.080.02proteinmRNASCNVmethylationUCEC0.000.07-0.02proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ACVR1C and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.