Basic information
- Full name
- activin A receptor type 1C
- Ensembl
- ENSG00000123612.16
- Summary
- ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
- Annotation
- Protein Kinase Receptor
Protein product
- ENST00000243349.13 Primary ENSP00000243349.7 (0 phosphosite)
- ENST00000409680.7
- ENST00000335450.7
- ENST00000348328.9
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.4e-3 | - | -4.3e-22 | - | - | 4.8e-9 | 1.1e-26 | 6.8e-3 | - | -1.0e-4 | - |
protein | - | - | - | - | - | - | - | - | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ACVR1C with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
cibersort: B cell plasma | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell CD4+ memory resting | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell regulatory (Tregs) | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: NK cell activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Macrophage M1 | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Myeloid dendritic cell activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Eosinophil | - | - | - | - | - | - | - | - | - | - | - | |
xcell: B cell | - | - | - | - | - | - | - | - | - | - | - | |
xcell: T cell CD8+ effector memory | - | - | - | - | - | - | - | - | - | - | - | |
xcell: Common myeloid progenitor | - | - | - | - | - | - | - | - | - | - | - |
Cis-association
Associations between omics data of ACVR1C
Trans-association
Associations of the protein abundance of ACVR1C and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.