Basic information

Full name
A-kinase anchoring protein 10
Ensembl
ENSG00000108599.15
Summary
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]

Protein product

Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.035-1.8e-10--6.5e-5-4.2e-7-4e-11--6.2e-4-
protein-1.5e-8--1.1e-9--2.3e-4-6.1e-12-1.7e-6-5.2e-50.0920.14

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC88.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer0123456789101112130-1-2-3-4-5-6-7-8-9-10-11-12-13proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of AKAP10 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Monocyte4.1e-70.50.210.840.833.5e-37.2e-3-0.980.0312.2e-33.8e-3
xcell: Neutrophil3.2e-60.630.10.350.160.0140.320.0450.550.0340.037
DISEASE-PSP_Alzheimer's_disease4.5e-6---7.6e-6-----0.044
HALLMARK_XENOBIOTIC_METABOLISM5.3e-60.234.4e-6-0.570.240.20.312.6e-39.8e-3-0.0370.029
HALLMARK_COAGULATION1.5e-50.670.16-0.570.570.161.7e-30.0470.120.460.002
xcell: Macrophage M21.2e-40.0411.6e-3-0.140.0470.380.0510.910.40.540.037
HALLMARK_APOPTOSIS1.2e-4-0.61-0.61-0.220.52.7e-31.4e-30.340.0250.0750.01
HALLMARK_COMPLEMENT1.6e-4-0.490.71-0.240.350.0178.1e-40.180.0860.365.8e-3
PROGENy: p532.1e-40.0430.550.461.3e-30.014-0.110.0120.16-0.340.2
HALLMARK_KRAS_SIGNALING_UP2.2e-4-0.65-0.2-0.440.130.0481.4e-40.0810.0370.570.014
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of AKAP10

BRCA0.650.490.56proteinmRNASCNVmethylationCCRCC0.330.050.09-0.150.17-0.14proteinmRNASCNVmethylationCOAD0.360.670.75proteinmRNASCNVmethylationGBM0.09-0.12-0.00-0.140.290.01proteinmRNASCNVmethylationHNSCC0.62-0.110.57-0.030.73-0.06proteinmRNASCNVmethylationLSCC0.71-0.240.67-0.180.85-0.18proteinmRNASCNVmethylationLUAD0.74-0.170.67-0.130.86-0.08proteinmRNASCNVmethylationOV0.370.340.68proteinmRNASCNVmethylationPDAC0.440.140.38-0.010.65-0.05proteinmRNASCNVmethylationUCEC0.530.010.29-0.000.310.14proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of AKAP10 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.