Basic information

Full name
albumin
Ensembl
ENSG00000163631.17
Summary
This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]
Annotation
Druggable target (Tier T2) Ligand

Protein product

  • ENST00000295897.9 Primary ENSP00000295897.4 (0 phosphosite)
  • ENST00000509063.5
  • ENST00000401494.7
  • ENST00000503124.5
  • ENST00000415165.6
  • ENST00000621628.4
  • ENST00000621085.4
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-7.7e-19--2.6e-27---0.33-1.5e-60.26--1.5e-5-
protein-1.2e-36-4.8e-3---1.8e-16-1.4e-33-2.1e-31-3.7e-41.3e-7-1.7e-9

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC121314151617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ALB with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: stroma score1.5e-231.5e-86.6e-6-5.6e-30.011.4e-70.293.8e-37.9e-50.18
HALLMARK_MYOGENESIS1.4e-223.9e-54.7e-5-0.0489.6e-31.4e-80.199.0e-68.4e-30.012
xcell: Endothelial cell5.2e-226.1e-61.4e-5-8.4e-33.1e-32.5e-112.2e-50.710.120.1
HALLMARK_UV_RESPONSE_DN2.3e-195.4e-102.1e-4-0.0720.729.2e-70.0169.7e-50.160.021
HALLMARK_TGF_BETA_SIGNALING3.6e-188.1e-94.3e-5-0.050.671.2e-40.0292.6e-60.0210.42
PATH-NP_EGFR1_PATHWAY2e-166.3e-40.15-0.0256.5e-41.5e-30.017-2.8e-80.1
ESTIMATE: StromalScore1e-152.4e-80.02-2.8e-30.122.0e-60.0740.0610.290.03
HALLMARK_KRAS_SIGNALING_UP3.4e-155.6e-60.049-0.0030.0428.1e-83.5e-40.110.990.11
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION5.5e-151.6e-63.1e-3-6.3e-30.533.4e-50.0313.1e-30.290.046
HALLMARK_APICAL_JUNCTION9.3e-151.1e-40.003-0.360.0272.5e-50.582.1e-45.7e-30.041
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ALB

BRCA0.13-0.040.26proteinmRNASCNVmethylationCCRCC0.01-0.010.10proteinmRNASCNVmethylationCOAD0.24proteinmRNASCNVmethylationGBM0.01-0.13-0.08proteinmRNASCNVmethylationHNSCC0.220.060.14proteinmRNASCNVmethylationLSCC0.020.020.19proteinmRNASCNVmethylationLUAD-0.21-0.300.08proteinmRNASCNVmethylationOV0.16-0.080.38proteinmRNASCNVmethylationPDAC-0.50-0.000.14proteinmRNASCNVmethylationUCEC-0.170.10-0.16proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ALB and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.