Gene: ALDH2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
aldehyde dehydrogenase 2 family member
Ensembl
ENSG00000111275.13
Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
Annotation
Druggable target (Tier T2)

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.2e-84--4.2e-22---1.4e-20-5.3e-34-5.1e-27--0.088-
protein-7.2e-44--1e-26-0.43--1.4e-22-5.5e-30-3.1e-8-0.003-0.148.4e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.52929.53030.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ALDH2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISM6.3e-190.0953.8e-57.2e-51.1e-30.262.3e-53.2e-60.462.9e-40.48
xcell: Hematopoietic stem cell4.8e-125.9e-3-0.440.336.9e-31.7e-31.8e-52.7e-89.3e-40.074-0.06
HALLMARK_XENOBIOTIC_METABOLISM1.5e-90.0028.7e-40.160.260.548.8e-33.0e-41.2e-30.38-0.43
cibersort: Mast cell activated5.5e-80.0320.890.0880.911.2e-36.9e-32.1e-40.0280.063-0.54
HALLMARK_HEME_METABOLISM1.9e-70.120.2-0.974.2e-40.13.2e-43.7e-40.40.049-0.13
PERT-P100-DIA_STAUROSPORINE1.9e-65.5e-3---0.40.120.0760.13-9.3e-40.012
HALLMARK_PEROXISOME4.7e-60.336.6e-31.9e-70.23-0.460.392.2e-3-0.080.0260.46
HALLMARK_ADIPOGENESIS5.3e-61.7e-52.6e-3-0.560.24-0.630.0135.0e-50.048-0.75-0.23
PROGENy: Androgen6.8e-60.046-0.6-0.130.0380.219.5e-42.8e-33.6e-30.0980.93
HALLMARK_FATTY_ACID_METABOLISM1.7e-53.7e-31.9e-3-0.960.83-0.630.451.5e-50.740.0840.45
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ALDH2

BRCA0.770.140.15proteinmRNASCNVmethylationCCRCC0.570.070.200.020.21-0.08proteinmRNASCNVmethylationCOAD0.540.040.16proteinmRNASCNVmethylationGBM0.710.03-0.09-0.020.040.06proteinmRNASCNVmethylationHNSCC0.70-0.030.01-0.080.15-0.01proteinmRNASCNVmethylationLSCC0.810.17-0.070.22-0.210.08proteinmRNASCNVmethylationLUAD0.66-0.000.13-0.110.20-0.09proteinmRNASCNVmethylationOV0.870.180.25proteinmRNASCNVmethylationPDAC0.660.030.12-0.080.180.03proteinmRNASCNVmethylationUCEC0.76-0.130.01-0.150.06-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ALDH2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.