Gene: ARHGDIB

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
Rho GDP dissociation inhibitor beta
Ensembl
ENSG00000111348.9
Summary
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.093-8.7e-29--0.75-1e-28-7.6e-6-0.62-
protein1.8e-6-1.5e-250.23-3.1e-5-3e-10-0.52-0.141.1e-34.2e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC25.52626.52727.52828.52929.53030.53131.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025303540450-5-10-15-20-25-30-35-40-45Pan-cancer0204060801001201401601800-20-40-60-80-100-120-140-160-180proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ARHGDIB with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore1.8e-939.1e-71.8e-56.7e-52.2e-162.2e-162.2e-163.3e-92.2e-162.5e-62.2e-16
xcell: microenvironment score1.5e-903e-92.2e-161.2e-32.2e-162.2e-162.2e-169.4e-82.2e-161.5e-33.8e-7
xcell: immune score8.6e-891.8e-40.0481.6e-42.2e-162.2e-162.2e-162.2e-162.2e-161.0e-52.2e-16
HALLMARK_ALLOGRAFT_REJECTION1.1e-846.0e-56.3e-43.3e-52.2e-162.2e-162.2e-162.4e-62.2e-161.6e-52.2e-16
ESTIMATE: ESTIMATEScore1.3e-845.6e-65.2e-80.0012.2e-162.2e-162.2e-162.4e-52.2e-161.9e-32.2e-16
HALLMARK_IL2_STAT5_SIGNALING6.7e-837.2e-67.1e-68.0e-42.2e-162.2e-162.2e-167.9e-62.2e-161.6e-32.2e-16
HALLMARK_COMPLEMENT6.5e-799.6e-67.3e-32.2e-42.2e-163.3e-182.2e-161.2e-42.2e-160.0012.2e-16
HALLMARK_IL6_JAK_STAT3_SIGNALING1.6e-771.3e-50.0214.0e-52.2e-162.2e-162.2e-162.8e-62.2e-160.0152.2e-16
HALLMARK_INFLAMMATORY_RESPONSE2.2e-777.4e-51.5e-32.1e-42.2e-162.2e-162.2e-164.6e-62.2e-160.0162.2e-16
HALLMARK_INTERFERON_GAMMA_RESPONSE2e-633.5e-53.1e-34.9e-42.2e-162.2e-162.2e-167.4e-32.4e-90.272.2e-16
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ARHGDIB

BRCA0.67-0.12-0.06proteinmRNASCNVmethylationCCRCC0.69-0.03-0.03proteinmRNASCNVmethylationCOAD0.150.220.13proteinmRNASCNVmethylationGBM0.880.170.12proteinmRNASCNVmethylationHNSCC0.77-0.17-0.17proteinmRNASCNVmethylationLSCC0.82-0.14-0.09proteinmRNASCNVmethylationLUAD0.740.10-0.03proteinmRNASCNVmethylationOV0.74-0.070.08proteinmRNASCNVmethylationPDAC0.520.140.20proteinmRNASCNVmethylationUCEC0.80-0.04-0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ARHGDIB and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.