Basic information

Full name
actin related protein 2/3 complex subunit 1A
Ensembl
ENSG00000241685.10
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Protein product

  • ENST00000262942.10 Primary ENSP00000262942.5 (0 phosphosite)
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.7e-72-3.3e-25--8.5e-66.7e-295.3e-19-1.3e-7-
protein-7.9e-50--7.4e-25-5.7e-31--2.8e-200.14-5.5e-24-0.150.016-1.1e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2222.52323.52424.52525.52626.52727.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ARPC1A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Hematopoietic stem cell2.4e-90.0414.7e-61.7e-3-0.820.81-0.522.1e-40.680.0869.0e-5
cibersort: Mast cell activated3.3e-90.573.8e-42.7e-30.220.220.650.0130.770.0922.3e-5
HALLMARK_HEDGEHOG_SIGNALING5.2e-8-0.730.190.476.0e-5-10.612.2e-40.340.0352.0e-5
KINASE-PSP_PAK14.5e-6----0.360.030.031-0.476e-70.035
xcell: stroma score5.5e-60.591.9e-53.2e-3-0.0290.91-0.0636.8e-30.654.6e-41.0e-4
KINASE-PSP_AMPKA1/PRKAA15.5e-6----0.27----2.2e-160.44
PERT-P100-DIA_STAUROSPORINE4.8e-50.21---0.410.10.0981.3e-3-6.5e-40.66
Tumor Purity (WGS)5.2e-5-0.045-1.6e-30.662.1e-4-0.71-0.026-0.65
PATH-NP_EGFR1_PATHWAY7.0e-50.50.480.089-0.173.5e-3-0.887.1e-3-1.1e-6-0.91
cibersort: T cell CD4+ memory resting1.4e-40.10.0170.0310.680.48-0.120.0260.941.4e-40.88
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ARPC1A

BRCA-0.06-0.120.45proteinmRNASCNVmethylationCCRCC0.15-0.010.02-0.060.660.03proteinmRNASCNVmethylationCOAD0.08-0.110.51proteinmRNASCNVmethylationGBM-0.11-0.100.230.190.540.01proteinmRNASCNVmethylationHNSCC-0.100.08-0.10-0.190.61-0.28proteinmRNASCNVmethylationLSCC0.150.01-0.080.060.63-0.00proteinmRNASCNVmethylationLUAD-0.16-0.08-0.24-0.080.620.09proteinmRNASCNVmethylationOV-0.02-0.100.59proteinmRNASCNVmethylationPDAC-0.030.15-0.01-0.000.560.07proteinmRNASCNVmethylationUCEC-0.13-0.04-0.07-0.180.41-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ARPC1A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.