Gene: ATP5F1E

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
ATP synthase F1 subunit epsilon
Ensembl
ENSG00000124172.10
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2.[provided by RefSeq, Mar 2011]

Protein product

  • ENST00000243997.8 Primary ENSP00000243997.3 (0 phosphosite)
  • ENST00000395659.1
  • ENST00000395663.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.5e-4--2.3e-5---0.0284.9e-83.6e-7-1.3e-5-
protein-2.5e-25--3e-26-3.5e-14--8.2e-180.011-9.2e-3-0.190.54-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC10.51111.51212.51313.51414.515log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADHNSCCLSCCLUADOVPDAC2424.52525.52626.52727.52828.52929.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer05101520253035400-5-10-15-20-25-30-35-40proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ATP5F1E with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_AMPKA1/PRKAA12.2e-16--------2.2e-16-
HALLMARK_OXIDATIVE_PHOSPHORYLATION2.5e-40.83.4e-50.023-0.270.20.410.13-0.31-
KINASE-PSP_PAK15.9e-4----0.050.87-0.992.0e-6-
HALLMARK_FATTY_ACID_METABOLISM6.4e-40.0322.5e-50.19-0.0120.340.990.77-0.074-
cibersort: Monocyte6.6e-40.310.0620.12-0.0410.220.6-0.330.018-
PERT-P100-DIA_STAUROSPORINE7.4e-40.21---0.1-0.650.33-3.4e-5-
KRAS mutation3.4e-3--0.058---0.025---
KINASE-PSP_MAPKAPK23.7e-3---0.35-0.035-0.16-0.291.5e-8-
HALLMARK_PEROXISOME5.5e-36.9e-41.6e-41.4e-3-0.42-0.81-0.11-0.94-0.16-
HALLMARK_BILE_ACID_METABOLISM0.0061.6e-31.7e-40.061-0.059-0.62-0.28-0.47-0.53-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ATP5F1E

BRCA0.14-0.040.33proteinmRNASCNVmethylationCCRCC0.200.040.01-0.010.22-0.09proteinmRNASCNVmethylationCOAD0.02-0.070.59proteinmRNASCNVmethylationGBM0.190.28-0.07proteinmRNASCNVmethylationHNSCC0.030.090.01-0.050.48-0.12proteinmRNASCNVmethylationLSCC-0.22-0.03-0.12-0.010.42-0.03proteinmRNASCNVmethylationLUAD-0.010.05-0.21-0.100.59-0.13proteinmRNASCNVmethylationOV0.010.010.46proteinmRNASCNVmethylationPDAC-0.130.20-0.10-0.420.31-0.09proteinmRNASCNVmethylationUCEC-0.100.25-0.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ATP5F1E and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.