Basic information

Full name
beta-1,4-galactosyltransferase 1
Ensembl
ENSG00000086062.12
Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.9e-5--5.1e-11--3.5e-30.015.7e-17-0.041-
protein2.5e-53-2.2e-66.1e-20--0.521.4e-188.6e-160.341.4e-158.5e-6

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC78910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC21.52222.52323.52424.52525.52626.52727.52828.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of B4GALT1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_GLYCOLYSIS9.7e-140.342.4e-40.82e-80.633.8e-32.0e-40.291.8e-40.25
HALLMARK_ANDROGEN_RESPONSE1.1e-102.0e-40.18-0.81.4e-80.550.10.0837.8e-4-0.187.9e-5
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION2.1e-80.0493.6e-3-0.122.2e-166.8e-30.001-0.820.10.035-8.9e-4
HALLMARK_COAGULATION2.2e-87.6e-34.6e-4-0.292.2e-160.0130.049-0.540.0830.1-4.6e-3
HALLMARK_HYPOXIA5.7e-70.0985.2e-3-0.25.7e-90.546.2e-30.0430.454.9e-3-0.034
KINASE-PSP_PAK16.1e-7---1.8e-60.0490.069-0.0290.580.36
PROGENy: TNFa6.7e-70.920.011-0.42.2e-160.520.220.260.0981.1e-3-0.027
HALLMARK_XENOBIOTIC_METABOLISM1.2e-69.8e-30.0570.712.2e-16-0.670.490.640.26-0.50.25
PATH-NP_LEPTIN_PATHWAY1.6e-6---1.6e-6------
HALLMARK_ESTROGEN_RESPONSE_EARLY2.1e-60.060.0330.732.2e-16-0.820.060.130.25-2.4e-40.069
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of B4GALT1

BRCA0.610.130.17proteinmRNASCNVmethylationCCRCC0.46-0.010.03-0.09-0.03-0.22proteinmRNASCNVmethylationCOAD0.300.210.31proteinmRNASCNVmethylationGBM0.74-0.080.23-0.030.29-0.20proteinmRNASCNVmethylationHNSCC0.60-0.110.50-0.090.61-0.15proteinmRNASCNVmethylationLSCC0.69-0.200.54-0.290.66-0.37proteinmRNASCNVmethylationLUAD0.42-0.010.29-0.070.63-0.17proteinmRNASCNVmethylationOV0.600.270.56proteinmRNASCNVmethylationPDAC0.40-0.150.32-0.080.40-0.24proteinmRNASCNVmethylationUCEC0.740.06-0.040.120.01-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of B4GALT1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.