Gene: BBIP1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
BBSome interacting protein 1
Ensembl
ENSG00000214413.9
Summary
This gene encodes one of eight proteins that form the BBSome complex and is essential for its assembly. The BBSome complex is involved in trafficking signal receptors to and from the cilia. Mutations in this gene result in Bardet-Biedl syndrome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Protein product

  • ENST00000448814.7 Primary ENSP00000436622.2 (0 phosphosite)
  • ENST00000652043.1
  • ENST00000605742.5
  • ENST00000454061.5
  • ENST00000652396.1
  • ENST00000651952.1
  • ENST00000652400.1
  • ENST00000447005.5
  • ENST00000436562.1
  • ENST00000423273.5
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.5e-17--0.016---0.75-5.6e-13-9.4e-13--0.045-
protein-1.9e-18--1.6e-19---6.1e-6-2.9e-7-4.0e-5-0.024-0.36

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC66.577.588.599.510log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADPDACUCEC161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BBIP1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_HEDGEHOG_SIGNALING1e-7-0.880.35-0.080.670.0454.5e-4-8.6e-37.8e-5
HALLMARK_MYOGENESIS2.6e-66.7e-30.65-0.910.221.3e-30.052-0.0330.13
PROGENy: TGFb8.8e-60.560.37-0.990.0134.9e-38.1e-3-0.0640.2
HALLMARK_UV_RESPONSE_DN1.9e-50.280.88-0.860.564.5e-38.7e-3-0.0190.022
xcell: Hematopoietic stem cell3.6e-50.130.045-0.75-0.470.0120.24-0.0170.013
HALLMARK_BILE_ACID_METABOLISM5.6e-50.230.11-0.0590.430.80.18-0.357.4e-4
xcell: Cancer associated fibroblast1.0e-40.057-0.84--0.910.60.0370.37-0.0391.2e-4
PERT-P100-DIA_STAUROSPORINE1.5e-46.7e-4--0.082-0.590.0190.016--0.640.26
xcell: stroma score1.6e-40.030.18--0.0210.756.4e-30.32-0.0663.6e-4
HALLMARK_NOTCH_SIGNALING3.8e-4-0.73-0.54-0.547.1e-30.0710.092-0.0110.091
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BBIP1

BRCA0.260.030.29proteinmRNASCNVmethylationCCRCC0.100.120.010.160.160.06proteinmRNASCNVmethylationCOAD0.34proteinmRNASCNVmethylationGBM0.070.02-0.04-0.330.47-0.52proteinmRNASCNVmethylationHNSCC-0.08-0.12-0.120.010.43-0.13proteinmRNASCNVmethylationLSCC0.170.170.32-0.030.46-0.01proteinmRNASCNVmethylationLUAD0.11-0.090.09-0.030.42-0.14proteinmRNASCNVmethylationOV0.33proteinmRNASCNVmethylationPDAC0.31-0.16-0.170.160.20-0.05proteinmRNASCNVmethylationUCEC0.510.090.250.080.580.26proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BBIP1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.