Gene: BCL2A1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
BCL2 related protein A1
Ensembl
ENSG00000140379.8
Summary
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4)

Protein product

  • ENST00000267953.4 Primary ENSP00000267953.3 (0 phosphosite)
  • ENST00000335661.6
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA8.2e-3-2.7e-24--1.5e-16-4e-14-2.1e-13-0.017-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC23456789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCALSCCLUAD13.413.613.81414.214.414.614.81515.215.415.615.816log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30Pan-cancer0204060801001201401601800-20-40-60-80-100-120-140-160-180proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BCL2A1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: NFkB4.9e-3-----2.7e-30.33---
xcell: NK cell0.011-----0.190.023---
HALLMARK_ANGIOGENESIS0.012-----0.0280.18---
PROGENy: TNFa0.014-----0.0120.34---
HALLMARK_COMPLEMENT0.016-----0.0440.16---
HALLMARK_IL6_JAK_STAT3_SIGNALING0.021-----0.0140.43---
PROGENy: EGFR0.022-----0.390.018---
cibersort: Neutrophil0.029-----0.080.18---
HALLMARK_INFLAMMATORY_RESPONSE0.042-----0.0210.57---
xcell: Neutrophil0.05-----0.20.14---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BCL2A1

BRCA0.11proteinmRNASCNVmethylationCCRCC-0.04proteinmRNASCNVmethylationCOAD0.22proteinmRNASCNVmethylationGBM0.13proteinmRNASCNVmethylationHNSCC-0.05proteinmRNASCNVmethylationLSCC0.65-0.37-0.02proteinmRNASCNVmethylationLUAD0.430.230.22proteinmRNASCNVmethylationOV0.11proteinmRNASCNVmethylationPDAC0.04proteinmRNASCNVmethylationUCEC-0.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BCL2A1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.