Gene: BIK

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
BCL2 interacting killer
Ensembl
ENSG00000100290.3
Summary
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

Protein product

  • ENST00000216115.3 Primary ENSP00000216115.2 (0 phosphosite)
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA6.1e-21--1.2e-25--0.0315.6e-312.4e-23-3.5e-8-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer024681012140-2-4-6-8-10-12-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BIK with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: T cell CD4+ central memory-----------
xcell: T cell CD4+ effector memory-----------
xcell: T cell CD8+ naive-----------
xcell: T cell CD8+-----------
xcell: T cell CD8+ central memory-----------
xcell: T cell CD8+ effector memory-----------
xcell: Class-switched memory B cell-----------
xcell: Common lymphoid progenitor-----------
xcell: Common myeloid progenitor-----------
xcell: Myeloid dendritic cell-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BIK

BRCA0.06proteinmRNASCNVmethylationCCRCC-0.040.160.03proteinmRNASCNVmethylationCOAD0.32proteinmRNASCNVmethylationGBM-0.030.17-0.07proteinmRNASCNVmethylationHNSCC0.040.300.11proteinmRNASCNVmethylationLSCC0.180.270.22proteinmRNASCNVmethylationLUAD-0.230.27-0.07proteinmRNASCNVmethylationOV0.26proteinmRNASCNVmethylationPDAC0.010.46-0.08proteinmRNASCNVmethylationUCEC-0.000.270.22proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BIK and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.