Basic information
- Full name
- bridging integrator 3
- Ensembl
- ENSG00000147439.13
- Summary
- The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]
Protein product
- ENST00000276416.11 Primary ENSP00000276416.6 (1 phosphosite)
- ENST00000399977.8
- ENST00000519513.5
- ENST00000520292.1
- ENST00000640731.1
- ENST00000522268.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -4.7e-7 | - | 0.038 | - | - | -3.2e-4 | -4.1e-12 | -5.8e-5 | - | 0.23 | - |
protein | -3.5e-29 | - | 8.4e-9 | -1.3e-25 | - | -1.2e-11 | -1.1e-31 | -3.7e-18 | -5.3e-8 | 6.9e-4 | 0.027 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of BIN3 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
PROGENy: p53 | 1.4e-23 | 1.9e-5 | 0.5 | 0.076 | 6.3e-4 | 9.8e-7 | 2.8e-4 | 1.9e-5 | 0.051 | 0.014 | 1.8e-5 | |
HALLMARK_ESTROGEN_RESPONSE_EARLY | 3.7e-22 | 1.6e-8 | -0.36 | -0.64 | 3.7e-8 | 0.073 | 2.0e-4 | 1.2e-3 | 4.9e-4 | 0.69 | 2.2e-16 | |
HALLMARK_ESTROGEN_RESPONSE_LATE | 5.6e-14 | 1.2e-6 | -0.029 | 0.089 | 1.8e-4 | 0.014 | 1.1e-4 | 0.065 | 0.047 | 0.42 | 2.6e-6 | |
PROGENy: Androgen | 1.3e-13 | 2.2e-16 | 0.76 | 0.78 | 0.034 | 0.99 | 0.099 | 0.008 | 7.5e-3 | 0.052 | 3.6e-4 | |
HALLMARK_BILE_ACID_METABOLISM | 3e-13 | 1.6e-7 | 2.1e-3 | 0.075 | 1.0e-5 | -0.14 | -0.86 | 1.4e-3 | 0.04 | 0.12 | 7.2e-4 | |
HALLMARK_HEME_METABOLISM | 2e-12 | 0.018 | 0.018 | 1.3e-3 | 3.8e-5 | 0.019 | 0.11 | 4.2e-6 | 0.37 | 0.25 | -0.67 | |
KINASE-PSP_Akt1/AKT1 | 6.6e-11 | 6.2e-6 | 0.54 | 0.52 | 1.7e-3 | 0.23 | 0.089 | 6.6e-4 | 0.41 | 0.024 | 0.018 | |
HALLMARK_ADIPOGENESIS | 3.2e-10 | 3.7e-6 | 0.012 | 0.037 | 4.3e-5 | 0.43 | 0.076 | 0.02 | 0.083 | -0.87 | 0.93 | |
HALLMARK_FATTY_ACID_METABOLISM | 5.1e-10 | 1.3e-4 | 9.4e-4 | 0.16 | 0.002 | 0.47 | 0.079 | 0.037 | 0.44 | 0.41 | 0.064 | |
HALLMARK_PEROXISOME | 1.3e-9 | 4.9e-5 | 7.0e-4 | 0.32 | 0.014 | 0.72 | 0.35 | 0.006 | 0.87 | 0.081 | 0.019 |
Cis-association
Associations between omics data of BIN3
Trans-association
Associations of the protein abundance of BIN3 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.