Basic information

Full name
bone morphogenetic protein 4
Ensembl
ENSG00000125378.16
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
Annotation
Ligand

Protein product

  • ENST00000245451.9 Primary ENSP00000245451.4 (0 phosphosite)
  • ENST00000417573.5
  • ENST00000559087.5
  • ENST00000558984.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.5e-14--0.017---2.5e-18-2.1e-17-0.015-1.3e-6-
protein0.11-----0.770.011----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC234567891011121314log2(RSEM+1)tumornormal
Protein expression
HNSCCLSCCPDAC13141516171819202122log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer05101520253035404550550-5-10-15-20-25-30-35-40-45-50-55proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BMP4 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Cancer associated fibroblast5.8e-3----0.0680.038----
xcell: Granulocyte-monocyte progenitor7.5e-3----0.334.8e-3----
xcell: B cell plasma0.011----0.0450.11----
KINASE-PSP_Akt1/AKT10.011----0.0980.052----
xcell: stroma score0.018----0.120.072----
KINASE-PSP_MAPKAPK20.019----0.170.053----
cibersort: B cell plasma0.021----0.290.028----
xcell: Eosinophil0.021----0.0660.15----
HALLMARK_ANDROGEN_RESPONSE0.021----0.150.069----
KINASE-PSP_GSK3B0.026----0.270.042----
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BMP4

BRCA0.14proteinmRNASCNVmethylationCCRCC-0.160.40-0.01proteinmRNASCNVmethylationCOAD0.27proteinmRNASCNVmethylationGBM-0.170.070.05proteinmRNASCNVmethylationHNSCC-0.05-0.03-0.070.060.160.03proteinmRNASCNVmethylationLSCC-0.040.22-0.03-0.070.15-0.07proteinmRNASCNVmethylationLUAD-0.42-0.080.04proteinmRNASCNVmethylationOV0.15proteinmRNASCNVmethylationPDAC-0.090.23-0.04proteinmRNASCNVmethylationUCEC-0.25-0.06-0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BMP4 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.