Gene: BNIP3

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
BCL2 interacting protein 3
Ensembl
ENSG00000176171.11
Summary
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.4e-29-2e-24--0.0122.9e-162.6e-16--4.9e-5-
protein6.5e-7-4.3e-4--0.572.2e-191.7e-30.13-4e-110.043

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC56789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer010203040506070800-10-20-30-40-50-60-70-80proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of BNIP3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: Hypoxia2.5e-180.334.4e-5-6.1e-34.3e-31.5e-60.0420.0380.0414.6e-6
HALLMARK_GLYCOLYSIS1.7e-110.0482.5e-6-0.530.0356.6e-30.690.440.0131.1e-5
xcell: T cell CD4+ Th11.5e-60.20.8-0.390.0390.0260.120.0920.0589.8e-3
Tumor Purity (WGS)1.7e-6-5.6e-3-0.0510.930.0010.011--0.271.7e-3
chromosomal instability1.6e-50.120.023-0.440.434.6e-50.130.110.970.75
HALLMARK_SPERMATOGENESIS3.4e-50.026-0.28-1.1e-30.643.7e-60.41-0.930.160.43
HALLMARK_MTORC1_SIGNALING7.2e-50.230.05--0.60.320.260.240.92.1e-35.9e-3
HALLMARK_PEROXISOME1.6e-40.0658.7e-6-0.27-0.450.2-0.350.650.150.014
HALLMARK_OXIDATIVE_PHOSPHORYLATION1.8e-40.123.2e-5--0.990.710.0240.680.087-0.680.23
Tumor Purity (ABSOLUTE)2.0e-40.860.012-0.0650.593.2e-30.10.22-0.0630.034
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of BNIP3

BRCA0.440.130.06proteinmRNASCNVmethylationCCRCC0.70-0.230.10-0.260.16-0.06proteinmRNASCNVmethylationCOAD0.10proteinmRNASCNVmethylationGBM0.56-0.150.070.130.04-0.06proteinmRNASCNVmethylationHNSCC0.53-0.14-0.00-0.090.160.02proteinmRNASCNVmethylationLSCC0.78-0.150.06-0.280.120.07proteinmRNASCNVmethylationLUAD0.40-0.210.29-0.020.270.15proteinmRNASCNVmethylationOV0.400.100.25proteinmRNASCNVmethylationPDAC0.55-0.10-0.03-0.25-0.030.10proteinmRNASCNVmethylationUCEC0.510.040.020.110.06-0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of BNIP3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.