Gene: CCL5

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
C-C motif chemokine ligand 5
Ensembl
ENSG00000271503.6
Summary
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Annotation
Ligand

Protein product

  • ENST00000603197.6 Primary ENSP00000474412.1 (0 phosphosite)
  • ENST00000605140.6
  • ENST00000605509.2
  • ENST00000651122.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.35-2.8e-25--5.3e-8-2.1e-7-3.1e-14--0.003-
protein-1.8e-3-2.1e-12--3.6e-3-9.9e-10-4e-10--0.013-0.006

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC4567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC14151617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025303540450-5-10-15-20-25-30-35-40-45Pan-cancer0204060801001201401601802000-20-40-60-80-100-120-140-160-180-200proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CCL5 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_ALLOGRAFT_REJECTION8.1e-842.2e-161.6e-7-8.2e-62.2e-162.2e-162.2e-160.0242.1e-72.2e-16
ESTIMATE: ImmuneScore3.4e-812.2e-162.8e-7-2.2e-52.2e-162.2e-162.2e-160.0715.2e-72.2e-16
HALLMARK_IL6_JAK_STAT3_SIGNALING1.8e-602.2e-166.4e-5-4.4e-72.2e-162.2e-161.2e-70.0823.2e-51.4e-5
xcell: T cell CD8+ central memory3.3e-603.9e-101e-10-0.0485e-101.3e-161.5e-100.0453.9e-66.3e-12
xcell: immune score4.6e-562.9e-93e-7-2.0e-51.2e-92.2e-162.4e-70.172.9e-32.2e-16
HALLMARK_INTERFERON_GAMMA_RESPONSE2.2e-552.2e-165.8e-6-2.8e-32.2e-162.2e-164.1e-70.131.2e-47.7e-6
HALLMARK_COMPLEMENT3.4e-542.2e-168.2e-5-1.0e-58.2e-122.2e-169.8e-70.119.7e-56.7e-6
HALLMARK_IL2_STAT5_SIGNALING1.5e-503.8e-92.7e-4-1.2e-62.2e-162.2e-164.7e-80.21.1e-35.1e-5
cibersort: T cell CD8+7.1e-502.2e-161.3e-8-0.382.2e-51e-144.7e-100.616.3e-71.3e-9
HALLMARK_INFLAMMATORY_RESPONSE2.4e-472.4e-82.3e-3-5.4e-62.2e-162.2e-162.2e-60.16.7e-46.8e-5
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CCL5

BRCA0.69-0.06-0.15proteinmRNASCNVmethylationCCRCC0.660.210.20proteinmRNASCNVmethylationCOAD-0.11proteinmRNASCNVmethylationGBM0.48-0.010.11proteinmRNASCNVmethylationHNSCC0.87-0.26-0.27proteinmRNASCNVmethylationLSCC0.86-0.12-0.18proteinmRNASCNVmethylationLUAD0.680.03-0.02proteinmRNASCNVmethylationOV0.570.160.01proteinmRNASCNVmethylationPDAC0.650.04-0.03proteinmRNASCNVmethylationUCEC0.76-0.17-0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CCL5 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.