Gene: CCR10

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
C-C motif chemokine receptor 10
Ensembl
ENSG00000184451.5
Summary
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
Annotation
Druggable target (Tier T4) Receptor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.0e-4-3.7e-5---0.089-1.7e-7-5.9e-4--0.014-
protein3.5e-4------3.5e-4---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789log2(RSEM+1)tumornormal
Protein expression
COADLUADPDAC12131415161718192021log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.00.0-0.5-1.0-1.5-2.0-2.5-3.0-3.5-4.0-4.5-5.0-5.5-6.0-6.5-7.0Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CCR10 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: B cell plasma3.5e-3--0.4---9.9e-4---
cibersort: B cell plasma9.1e-3--0.76---7.3e-4---
HALLMARK_ESTROGEN_RESPONSE_LATE0.011--0.074---0.067---
HALLMARK_TGF_BETA_SIGNALING0.027--0.79---4.3e-3---
xcell: T cell CD4+ effector memory0.03--0.75---5.7e-3---
xcell: T cell CD4+ central memory0.042--0.088---0.24---
HALLMARK_CHOLESTEROL_HOMEOSTASIS0.051--0.016---0.72---
HALLMARK_KRAS_SIGNALING_DN0.053--0.21---0.14---
xcell: T cell regulatory (Tregs)0.054--0.073---0.35---
xcell: B cell memory0.058--0.13---0.25---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CCR10

BRCA0.07proteinmRNASCNVmethylationCCRCC-0.150.13-0.03proteinmRNASCNVmethylationCOAD0.51-0.170.01proteinmRNASCNVmethylationGBM-0.15-0.01-0.04proteinmRNASCNVmethylationHNSCC-0.36-0.020.15proteinmRNASCNVmethylationLSCC-0.24-0.260.37proteinmRNASCNVmethylationLUAD0.12-0.17-0.12-0.400.050.26proteinmRNASCNVmethylationOV0.13proteinmRNASCNVmethylationPDAC-0.230.140.15proteinmRNASCNVmethylationUCEC-0.45-0.040.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CCR10 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.