Gene: CD160

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
CD160 molecule
Ensembl
ENSG00000117281.16
Summary
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
Annotation
Ligand

Protein product

  • ENST00000369288.7 Primary ENSP00000358294.1 (0 phosphosite)
  • ENST00000235933.10
  • ENST00000401557.7
  • ENST00000616463.1
  • ENST00000584442.2
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.2e-19-5.3e-11---2.8e-3-1.8e-21-1.4e-23--1.5e-5-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC12345678910log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CD160 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: NK cell activated-----------
cibersort: Monocyte-----------
cibersort: Macrophage M0-----------
cibersort: Macrophage M1-----------
cibersort: Macrophage M2-----------
cibersort: Myeloid dendritic cell resting-----------
cibersort: Myeloid dendritic cell activated-----------
cibersort: Mast cell activated-----------
xcell: Cancer associated fibroblast-----------
xcell: Granulocyte-monocyte progenitor-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CD160

BRCA0.13proteinmRNASCNVmethylationCCRCC-0.10proteinmRNASCNVmethylationCOAD0.15proteinmRNASCNVmethylationGBM0.15proteinmRNASCNVmethylationHNSCC0.12proteinmRNASCNVmethylationLSCC0.11proteinmRNASCNVmethylationLUAD0.43proteinmRNASCNVmethylationOV0.30proteinmRNASCNVmethylationPDAC-0.03proteinmRNASCNVmethylationUCEC0.33proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CD160 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.