Gene: CD1C

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
CD1c molecule
Ensembl
ENSG00000158481.13
Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T5)

Protein product

  • ENST00000368170.8 Primary ENSP00000357152.3 (0 phosphosite)
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.7e-33--0.056---1.5e-12-2.4e-26-6.8e-7--0.016-
protein-0.9------0.130.19---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011log2(RSEM+1)tumornormal
Protein expression
CCRCCHNSCCLSCCLUAD1213141516171819202122log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer010203040506070800-10-20-30-40-50-60-70-80proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CD1C with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Myeloid dendritic cell9e-22----2.2e-163.9e-83.7e-3---
cibersort: Myeloid dendritic cell resting9.4e-7----0.363.6e-46.2e-5---
xcell: immune score1.3e-6----2.5e-31.4e-60.6---
xcell: T cell CD4+ effector memory2.6e-6----6.9e-38.7e-50.13---
xcell: Myeloid dendritic cell activated6.5e-6----0.0171.9e-50.25---
ESTIMATE: ImmuneScore1.0e-5----2.3e-39.1e-60.87---
xcell: microenvironment score1.1e-5----1.9e-31.7e-50.84---
HALLMARK_IL2_STAT5_SIGNALING2.2e-5----7.1e-43.1e-40.72---
PROGENy: Trail2.2e-5----0.229.0e-60.093---
ESTIMATE: ESTIMATEScore3.6e-5----2.7e-31.6e-40.69---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CD1C

BRCA-0.30proteinmRNASCNVmethylationCCRCC-0.02proteinmRNASCNVmethylationCOAD-0.12proteinmRNASCNVmethylationGBM0.16proteinmRNASCNVmethylationHNSCC0.52-0.14-0.25proteinmRNASCNVmethylationLSCC0.72-0.16-0.32proteinmRNASCNVmethylationLUAD0.740.30-0.17proteinmRNASCNVmethylationOV-0.11proteinmRNASCNVmethylationPDAC0.04proteinmRNASCNVmethylationUCEC-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CD1C and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.