Gene: CD8A

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
CD8a molecule
Ensembl
ENSG00000153563.15
Summary
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
Annotation
Druggable target (Tier T5)

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.56-8.5e-23--0.014-1.3e-4-3.0e-6--5.4e-4-
protein9.7e-3-1.2e-17-0.22--0.83-9.5e-4-5.1e-7-0.058-0.01-0.19

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1818.51919.52020.52121.52222.52323.52424.525log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530354045500-5-10-15-20-25-30-35-40-45-50Pan-cancer0204060801001201401601802002202400-20-40-60-80-100-120-140-160-180-200-220-240proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CD8A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: T cell CD8+1.2e-1222.2e-162.2e-162.2e-160.0112.2e-195.6e-202.2e-161.2e-192.5e-69e-13
HALLMARK_ALLOGRAFT_REJECTION7.3e-942.2e-162.2e-164.4e-70.0372.2e-162.2e-167.4e-92.2e-165.2e-69.4e-11
xcell: T cell CD8+ central memory5.9e-906.9e-126.5e-176.7e-100.0433.4e-204e-191.3e-88.1e-104.1e-82.2e-6
ESTIMATE: ImmuneScore1.8e-892.2e-162.2e-165.6e-60.0612.2e-162.2e-166.8e-82.2e-161.1e-61.3e-8
xcell: T cell CD8+1.5e-681.2e-102e-188e-8-0.155.5e-178.6e-181.4e-73.5e-84.4e-76.4e-4
xcell: immune score4e-589.4e-107.1e-103.5e-50.22.2e-162.2e-161.2e-51.2e-50.0021.2e-6
xcell: microenvironment score5.7e-582.2e-161.4e-61.8e-40.222.2e-162.2e-168.1e-63.5e-73.8e-31.1e-4
ESTIMATE: ESTIMATEScore6.4e-586.7e-114.1e-76.5e-40.112.2e-162.2e-164.7e-51.7e-81.8e-42.2e-5
PROGENy: Trail2.4e-552.2e-162.2e-161.1e-30.712e-82.2e-162.3e-32.4e-87.9e-51.8e-3
HALLMARK_IL6_JAK_STAT3_SIGNALING5.8e-554.9e-112.3e-52.0e-40.192.2e-162.2e-162.1e-51.5e-61.5e-42.0e-5
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CD8A

BRCA0.710.010.12proteinmRNASCNVmethylationCCRCC0.79-0.21-0.03-0.14-0.140.10proteinmRNASCNVmethylationCOAD0.81-0.17-0.27proteinmRNASCNVmethylationGBM0.370.13-0.10-0.14-0.08-0.05proteinmRNASCNVmethylationHNSCC0.82-0.06-0.23-0.06-0.28-0.01proteinmRNASCNVmethylationLSCC0.930.30-0.300.37-0.35-0.19proteinmRNASCNVmethylationLUAD0.700.060.030.060.170.22proteinmRNASCNVmethylationOV0.870.010.05proteinmRNASCNVmethylationPDAC0.630.250.000.070.090.03proteinmRNASCNVmethylationUCEC0.750.18-0.090.12-0.03-0.28proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CD8A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.