Basic information

Full name
cell division cycle 25B
Ensembl
ENSG00000101224.17
Summary
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4) Phosphatase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA7.6e-30-4.1e-4--6.6e-213.1e-93.1e-4-3.4e-3-
protein0.012----0.661.9e-3----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCAHNSCCLSCC14.51515.51616.51717.51818.519log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025303540450-5-10-15-20-25-30-35-40-45proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CDC25B with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_DNA_REPAIR5.9e-30.43---0.283.7e-3----
HALLMARK_MYC_TARGETS_V26.7e-30.17---0.517.4e-3----
cibersort: Macrophage M07.1e-3-0.73---4.7e-30.029----
HALLMARK_E2F_TARGETS0.0150.15---0.830.011----
PERT-PSP_NOCODAZOLE0.0180.013----0.430.017----
KINASE-PSP_mTOR/MTOR0.0192.6e-4----0.73-----
KINASE-PSP_CK2A1/CSNK2A10.0220.003---0.450.8----
HALLMARK_G2M_CHECKPOINT0.0220.29---0.620.016----
xcell: NK cell0.0240.49---0.110.11----
Clinical: Path_Stage_pT0.030.02---0.170.95----
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CDC25B

BRCA0.340.280.36proteinmRNASCNVmethylationCCRCC-0.090.300.07proteinmRNASCNVmethylationCOAD0.57proteinmRNASCNVmethylationGBM0.070.450.21proteinmRNASCNVmethylationHNSCC0.09-0.130.120.020.340.17proteinmRNASCNVmethylationLSCC0.270.470.060.090.390.13proteinmRNASCNVmethylationLUAD0.030.280.21proteinmRNASCNVmethylationOV0.34proteinmRNASCNVmethylationPDAC0.090.410.24proteinmRNASCNVmethylationUCEC0.020.250.20proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CDC25B and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.