Basic information

Full name
cyclin dependent kinase 2 associated protein 1
Ensembl
ENSG00000111328.7
Summary
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Protein product

  • ENST00000261692.7 Primary ENSP00000261692.2 (0 phosphosite)
  • ENST00000542174.5
  • ENST00000535979.5
  • ENST00000538446.5
  • ENST00000618072.4
  • ENST00000544658.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.4e-54-3.7e-18--6.0e-44.4e-278.5e-19-3.1e-3-
protein9.2e-15-7.8e-6--3.7e-37.5e-209.3e-8-0.970.56-0.06

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer012345678910110-1-2-3-4-5-6-7-8-9-10-11proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CDK2AP1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETS2.3e-83.6e-3-0.23-2.4e-69.5e-32.7e-60.280.280.071-0.37
HALLMARK_WNT_BETA_CATENIN_SIGNALING3.3e-82.8e-54.2e-5-0.0550.740.015-0.910.50.610.011
HALLMARK_G2M_CHECKPOINT7.7e-82.2e-3-0.9-1.8e-64.1e-37.3e-50.470.840.2-0.51
chromosomal instability1.2e-60.088-7.3e-3-1.8e-46.8e-35.3e-100.20.081-0.70.81
Tumor Purity (WGS)1.3e-6--0.004-7.5e-92.4e-38.2e-100.79-0.740.89
HALLMARK_SPERMATOGENESIS1.6e-60.0580.53-6.3e-38.3e-45.7e-60.890.380.28-0.4
KINASE-PSP_CDK23.1e-61.2e-30.35-1.3e-50.350.0160.410.22-0.840.78
xcell: T cell CD4+ Th12.9e-50.140.34-4.1e-70.0722.4e-30.430.38-0.95-0.17
HALLMARK_MYC_TARGETS_V23.6e-56.2e-3-0.08-2.8e-30.0241.6e-7-0.618.4e-30.86-0.17
Tumor Purity (ABSOLUTE)1.2e-40.59-0.024-8.1e-50.027.2e-70.550.066-0.74-0.93
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CDK2AP1

BRCA0.540.270.26proteinmRNASCNVmethylationCCRCC0.38-0.43-0.06-0.130.150.14proteinmRNASCNVmethylationCOAD0.29proteinmRNASCNVmethylationGBM0.30-0.33-0.01-0.210.20-0.01proteinmRNASCNVmethylationHNSCC0.28-0.100.09-0.160.110.21proteinmRNASCNVmethylationLSCC0.53-0.210.39-0.410.270.11proteinmRNASCNVmethylationLUAD0.32-0.250.05-0.210.410.11proteinmRNASCNVmethylationOV0.300.050.37proteinmRNASCNVmethylationPDAC0.270.060.04-0.090.300.05proteinmRNASCNVmethylationUCEC0.17-0.090.28-0.420.23-0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CDK2AP1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.