Basic information

Full name
CCAAT enhancer binding protein beta
Ensembl
ENSG00000172216.6
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Annotation
Transcription factor

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.6e-3-6.6e-18--8e-11-5.7e-13-1.6e-4-9.2e-3-
protein4.4e-25-1.5e-151.2e-26-3.3e-16-0.180.58-0.878.8e-5-0.59

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC6.577.588.599.51010.51111.51212.51313.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2020.52121.52222.52323.52424.52525.52626.527log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CEBPB with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TNFa4.4e-522.2e-162.0e-59.7e-57.8e-95.7e-47.8e-89.0e-50.541.5e-52.2e-16
PROGENy: NFkB4e-482.2e-161.6e-42.0e-43.3e-92.5e-32.8e-77.8e-50.553.9e-42.2e-16
HALLMARK_INFLAMMATORY_RESPONSE6.3e-412e-85.2e-84.8e-42.2e-160.0162.5e-73.3e-30.761.2e-32.4e-8
HALLMARK_TNFA_SIGNALING_VIA_NFKB2.9e-351.1e-53.7e-53.6e-42.2e-101.1e-45e-82.5e-40.711.6e-32.1e-5
HALLMARK_IL6_JAK_STAT3_SIGNALING2e-339e-81.1e-64.9e-32.2e-160.323.8e-70.0030.850.0142.4e-7
xcell: Monocyte7.2e-310.0212.0e-60.0125.6e-120.032.5e-102.8e-5-0.774.8e-62.1e-3
HALLMARK_COMPLEMENT4.6e-256.0e-69e-82.9e-36.1e-90.436e-70.0160.860.15.5e-5
HALLMARK_HYPOXIA4.3e-241.1e-35.8e-50.0032.4e-90.0281.9e-45.1e-4-0.941.2e-31.1e-3
cibersort: Neutrophil2.5e-180.0687.5e-30.0262.8e-30.0210.0011.5e-5-0.755.7e-61.7e-4
HALLMARK_APOPTOSIS1.6e-170.0612.1e-52.6e-37.7e-80.0475.9e-60.220.910.122.5e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CEBPB

BRCA0.780.370.35proteinmRNASCNVmethylationCCRCC0.600.100.340.000.290.06proteinmRNASCNVmethylationCOAD0.420.230.40proteinmRNASCNVmethylationGBM0.650.05-0.060.020.040.04proteinmRNASCNVmethylationHNSCC0.690.260.240.230.210.11proteinmRNASCNVmethylationLSCC0.750.160.330.130.190.24proteinmRNASCNVmethylationLUAD0.600.120.120.150.280.21proteinmRNASCNVmethylationOV0.540.260.31proteinmRNASCNVmethylationPDAC0.38-0.000.09-0.19-0.000.01proteinmRNASCNVmethylationUCEC0.680.180.250.280.280.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CEBPB and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.