Basic information

Full name
class II major histocompatibility complex transactivator
Ensembl
ENSG00000179583.19
Summary
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Annotation
Cancer driver (TSG)

Protein product

  • ENST00000618327.4 Primary ENSP00000485010.1 (0 phosphosite)
  • ENST00000324288.13
  • ENST00000381835.9
  • ENST00000618207.4
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-6.8e-3-5.6e-13--0.099-8.6e-19-0.055--3.6e-5-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC67891011121314log2(RSEM+1)tumornormal
Protein expression
BRCALUAD121314151617181920log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer01020304050607080901000-10-20-30-40-50-60-70-80-90-100proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CIITA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PATH-NP_EGFR1_PATHWAY8.2e-48.2e-4---------
HALLMARK_TNFA_SIGNALING_VIA_NFKB6.5e-36.5e-3---------
HALLMARK_TGF_BETA_SIGNALING6.9e-36.9e-3---------
HALLMARK_APICAL_JUNCTION0.0120.012---------
HALLMARK_KRAS_SIGNALING_UP0.0120.012---------
cibersort: Neutrophil0.0140.014---------
PROGENy: WNT0.0170.017---------
cibersort: Macrophage M10.0210.021---------
PROGENy: NFkB0.0230.023---------
HALLMARK_INFLAMMATORY_RESPONSE0.0240.024---------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CIITA

BRCA0.36-0.400.06proteinmRNASCNVmethylationCCRCC0.16proteinmRNASCNVmethylationCOAD0.11proteinmRNASCNVmethylationGBM0.34proteinmRNASCNVmethylationHNSCC-0.01proteinmRNASCNVmethylationLSCC0.08proteinmRNASCNVmethylationLUAD0.35proteinmRNASCNVmethylationOV0.20proteinmRNASCNVmethylationPDAC0.01proteinmRNASCNVmethylationUCEC0.13proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CIITA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.