Gene: CLIC2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
chloride intracellular channel 2
Ensembl
ENSG00000155962.13
Summary
This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.8e-16-4.7e-28---1.7e-3-8.4e-34-7.7e-19--0.012-
protein-3e-62-0.039-2.1e-29--1.6e-17-2.1e-35-1.3e-31-3.5e-70.005-0.003

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC5678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC212223242526272829log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer01020304050607080901001101200-10-20-30-40-50-60-70-80-90-100-110-120proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CLIC2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: microenvironment score6.7e-902.2e-161.7e-72.6e-72.2e-162.2e-162.2e-161.6e-31.2e-93.5e-32.2e-16
ESTIMATE: ESTIMATEScore2.2e-822.2e-161.2e-32.0e-52.2e-162.2e-162.2e-160.0752.2e-160.0242.2e-16
ESTIMATE: ImmuneScore3.3e-662.2e-160.0124.4e-62.2e-162.2e-162.2e-167.3e-38.3e-90.0516.1e-5
HALLMARK_ALLOGRAFT_REJECTION1.7e-642.2e-160.0691.2e-52.2e-162.2e-162.2e-160.0432.2e-160.0690.011
HALLMARK_IL2_STAT5_SIGNALING1.7e-602.2e-161.2e-41.4e-42.1e-62.2e-162.2e-160.112.2e-160.16.3e-4
PROGENy: Trail2.7e-504.9e-70.276.7e-63.3e-32.2e-162.2e-162.6e-52.1e-78.9e-51.2e-4
xcell: immune score1.9e-484.8e-70.62.0e-62.2e-162.2e-162.2e-165.1e-31.4e-40.0370.009
ESTIMATE: StromalScore2.8e-468.1e-50.0146.1e-42.2e-163e-71.7e-80.385.9e-80.0612.2e-16
xcell: stroma score1.2e-454.5e-33.5e-44.3e-41.8e-39.6e-82.2e-160.0111.9e-62.8e-76.5e-9
HALLMARK_KRAS_SIGNALING_UP1.2e-441.8e-72.1e-39.7e-41.8e-86.6e-62.2e-160.222.9e-71.1e-32.0e-6
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* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CLIC2

BRCA0.73-0.060.07proteinmRNASCNVmethylationCCRCC0.76-0.12-0.22proteinmRNASCNVmethylationCOAD0.510.210.01proteinmRNASCNVmethylationGBM0.84-0.04-0.01proteinmRNASCNVmethylationHNSCC0.770.01-0.03proteinmRNASCNVmethylationLSCC0.84-0.34-0.21proteinmRNASCNVmethylationLUAD0.78-0.010.12proteinmRNASCNVmethylationOV0.690.120.10proteinmRNASCNVmethylationPDAC0.640.190.05proteinmRNASCNVmethylationUCEC0.83-0.05-0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CLIC2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.