Basic information
- Full name
- CDC like kinase 2
- Ensembl
- ENSG00000176444.19
- Summary
- This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
- Annotation
- Essential genes Druggable target (Tier T4) Protein Kinase
Protein product
- ENST00000368361.9 Primary ENSP00000357345.4 (12 phosphosites)
- ENST00000361168.9
- ENST00000355560.4
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.1e-34 | - | 3.4e-6 | - | - | 5.2e-3 | 6.8e-21 | 1.1e-17 | - | 0.036 | - |
protein | 2.9e-4 | - | 8.3e-4 | - | - | 9.7e-3 | 7.4e-10 | -0.75 | -0.39 | -0.027 | 0.37 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of CLK2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
chromosomal instability | 8.0e-6 | 1.4e-3 | -0.27 | - | -0.75 | 6.0e-4 | 1.6e-8 | 0.97 | 2.3e-3 | -0.014 | 0.052 | |
HALLMARK_E2F_TARGETS | 1.5e-5 | 1.2e-6 | -0.47 | - | -0.41 | 0.12 | 4.3e-7 | 0.23 | -0.75 | 0.25 | 0.32 | |
HALLMARK_MYC_TARGETS_V2 | 1.8e-5 | 1.7e-6 | -0.26 | - | 0.94 | 0.41 | 3.5e-5 | 0.12 | 0.64 | 0.53 | 0.13 | |
HALLMARK_G2M_CHECKPOINT | 3.0e-5 | 9.7e-5 | -0.31 | - | -0.34 | 0.029 | 2.7e-6 | 0.092 | -0.51 | 0.19 | 0.17 | |
HALLMARK_SPERMATOGENESIS | 7.4e-5 | 4.1e-4 | -0.93 | - | -0.047 | 3.7e-3 | 6.3e-6 | 0.3 | 0.31 | 0.58 | 0.68 | |
PATH-NP_LEPTIN_PATHWAY | 1.1e-4 | - | - | - | 1.1e-4 | - | - | - | - | - | - | |
KINASE-PSP_CK2A1/CSNK2A1 | 5.8e-4 | 0.014 | 0.85 | - | 0.63 | 0.038 | 0.032 | 0.12 | -0.4 | 0.049 | 0.76 | |
KINASE-PSP_RSK2/RPS6KA3 | 7.0e-4 | - | - | - | 7.0e-4 | - | - | - | - | - | - | |
HALLMARK_MYC_TARGETS_V1 | 7.2e-4 | 5.8e-6 | 0.68 | - | -0.93 | 0.87 | 2.4e-4 | 0.58 | -0.55 | 0.23 | 0.78 | |
HALLMARK_MITOTIC_SPINDLE | 8.4e-4 | 2.2e-3 | 0.19 | - | -0.54 | 0.53 | 0.026 | 0.28 | 0.41 | 0.25 | 0.73 |
Cis-association
Associations between omics data of CLK2
Trans-association
Associations of the protein abundance of CLK2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.