Basic information

Full name
chymase 1
Ensembl
ENSG00000092009.10
Summary
This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
Annotation
Druggable target (Tier T4)

Protein product

  • ENST00000250378.7 Primary ENSP00000250378.3 (0 phosphosite)
  • ENST00000206446.4
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.3e-48--1.4e-4---1.9e-16-2.6e-23-1.7e-11--5.2e-5-
protein-3e-63--0.53-1.3e-27--8.6e-20-8.6e-31-2.7e-19-3.5e-98.6e-3-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADHNSCCLSCCLUADOVPDACUCEC192021222324252627282930log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer05101520253035400-5-10-15-20-25-30-35-40proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CMA1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: stroma score1.6e-412.2e-162.5e-54.6e-7-1.6e-37.7e-67.4e-44.5e-44.2e-46.2e-7
xcell: Hematopoietic stem cell1.3e-321.5e-93.6e-71.8e-3-9.3e-46.0e-63.7e-60.0124.6e-33.1e-4
ESTIMATE: StromalScore2.9e-316.2e-74.8e-47.6e-6-8.2e-43.5e-50.177.5e-45.6e-43.9e-10
HALLMARK_MYOGENESIS3.8e-304.8e-65.4e-41.5e-4-5.0e-55.1e-32.3e-31.7e-50.0023.5e-7
HALLMARK_UV_RESPONSE_DN9e-286.3e-82.7e-39.2e-4-4.3e-34.0e-50.0353.8e-60.0911.5e-8
xcell: Cancer associated fibroblast2.7e-271.4e-67.7e-34.2e-6-2.4e-37.1e-48.6e-40.0155.7e-42.0e-6
xcell: microenvironment score2.7e-236.4e-30.0838.4e-6-1.2e-55.1e-52.8e-30.0510.0071.3e-6
HALLMARK_KRAS_SIGNALING_UP7.8e-231.6e-30.0273.8e-5-1.6e-35.8e-70.366.6e-32.3e-32.2e-7
ESTIMATE: ESTIMATEScore3.8e-210.010.19.0e-5-3.3e-52.2e-50.130.0181.3e-32.7e-6
xcell: Endothelial cell2.9e-201.7e-67.7e-49.3e-4-0.171.1e-60.030.720.0212.6e-7
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CMA1

BRCA0.620.040.09proteinmRNASCNVmethylationCCRCC0.600.230.21proteinmRNASCNVmethylationCOAD0.640.04-0.04proteinmRNASCNVmethylationGBM0.19proteinmRNASCNVmethylationHNSCC0.64-0.10-0.04proteinmRNASCNVmethylationLSCC0.52-0.010.12proteinmRNASCNVmethylationLUAD0.52-0.000.21proteinmRNASCNVmethylationOV0.540.13-0.00proteinmRNASCNVmethylationPDAC0.510.03-0.07proteinmRNASCNVmethylationUCEC0.450.05-0.17proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CMA1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.