Basic information
- Full name
- CCHC-type zinc finger nucleic acid binding protein
- Ensembl
- ENSG00000169714.17
- Summary
- This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
- Annotation
- Cancer driver (TSG)
Protein product
- ENST00000422453.7 Primary ENSP00000410619.3 (10 phosphosites)
- ENST00000441626.6
- ENST00000451728.6
- ENST00000446936.6
- ENST00000502976.5
- ENST00000504813.5
- ENST00000500450.6
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.9e-4 | - | 1.3e-9 | - | - | 3.7e-3 | 2.4e-6 | -8.1e-9 | - | 0.67 | - |
protein | 2.4e-24 | - | -0.22 | 1.3e-3 | - | 1.6e-11 | 1.2e-34 | 3.9e-33 | -0.13 | -0.051 | -0.47 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of CNBP with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_G2M_CHECKPOINT | 1.1e-11 | 0.5 | 0.51 | 0.049 | 0.014 | 0.13 | 9.9e-9 | 0.41 | 0.077 | 0.021 | 3.9e-4 | |
HALLMARK_E2F_TARGETS | 3.6e-11 | 0.54 | 0.38 | 0.011 | 0.021 | 0.37 | 1.5e-8 | 0.38 | 0.37 | 8.1e-3 | 3.0e-4 | |
HALLMARK_MYC_TARGETS_V2 | 5.4e-11 | 0.46 | 0.24 | 0.058 | 0.078 | 0.15 | 3.4e-9 | 0.18 | -0.87 | 1.1e-3 | 7.2e-4 | |
HALLMARK_DNA_REPAIR | 5.6e-11 | -0.69 | 3.8e-3 | 0.016 | 0.11 | 0.077 | 1e-8 | 0.049 | -0.29 | 2.8e-3 | 5.2e-3 | |
Tumor Purity (WGS) | 3.5e-10 | - | 0.025 | - | 0.016 | 0.01 | 6.6e-10 | 0.96 | - | 2.4e-4 | -0.61 | |
chromosomal instability | 6.8e-10 | 0.24 | 0.11 | -0.87 | 0.084 | 0.084 | 2.2e-16 | 0.95 | 0.4 | 0.011 | 0.076 | |
xcell: T cell CD4+ Th1 | 1.7e-8 | -0.6 | 0.38 | 0.36 | 0.23 | 0.071 | 5.8e-6 | 0.068 | 0.17 | 5.6e-3 | 2.3e-3 | |
HALLMARK_MYC_TARGETS_V1 | 1.8e-8 | -0.86 | 0.034 | 0.52 | 0.34 | 0.21 | 2.2e-10 | 0.11 | -0.97 | 9.5e-4 | 0.07 | |
Tumor Purity (ABSOLUTE) | 5.3e-5 | 0.031 | 0.34 | 0.69 | 0.023 | 0.021 | 1.3e-6 | -0.57 | -0.74 | 0.65 | 0.78 | |
HALLMARK_MITOTIC_SPINDLE | 5.8e-5 | 0.42 | 0.54 | 0.32 | 0.24 | -0.88 | 0.046 | 0.57 | 0.2 | 0.039 | 8.7e-4 |
Cis-association
Associations between omics data of CNBP
Trans-association
Associations of the protein abundance of CNBP and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.