Basic information

Full name
CCHC-type zinc finger nucleic acid binding protein
Ensembl
ENSG00000169714.17
Summary
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Annotation
Cancer driver (TSG)

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.9e-4-1.3e-9--3.7e-32.4e-6-8.1e-9-0.67-
protein2.4e-24--0.221.3e-3-1.6e-111.2e-343.9e-33-0.13-0.051-0.47

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC11.51212.51313.51414.51515.516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC19202122232425262728293031log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025300-5-10-15-20-25-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CNBP with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_G2M_CHECKPOINT1.1e-110.50.510.0490.0140.139.9e-90.410.0770.0213.9e-4
HALLMARK_E2F_TARGETS3.6e-110.540.380.0110.0210.371.5e-80.380.378.1e-33.0e-4
HALLMARK_MYC_TARGETS_V25.4e-110.460.240.0580.0780.153.4e-90.18-0.871.1e-37.2e-4
HALLMARK_DNA_REPAIR5.6e-11-0.693.8e-30.0160.110.0771e-80.049-0.292.8e-35.2e-3
Tumor Purity (WGS)3.5e-10-0.025-0.0160.016.6e-100.96-2.4e-4-0.61
chromosomal instability6.8e-100.240.11-0.870.0840.0842.2e-160.950.40.0110.076
xcell: T cell CD4+ Th11.7e-8-0.60.380.360.230.0715.8e-60.0680.175.6e-32.3e-3
HALLMARK_MYC_TARGETS_V11.8e-8-0.860.0340.520.340.212.2e-100.11-0.979.5e-40.07
Tumor Purity (ABSOLUTE)5.3e-50.0310.340.690.0230.0211.3e-6-0.57-0.740.650.78
HALLMARK_MITOTIC_SPINDLE5.8e-50.420.540.320.24-0.880.0460.570.20.0398.7e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CNBP

BRCA0.110.160.22proteinmRNASCNVmethylationCCRCC0.44-0.020.370.210.450.21proteinmRNASCNVmethylationCOAD0.130.160.12proteinmRNASCNVmethylationGBM-0.00-0.050.12-0.010.300.07proteinmRNASCNVmethylationHNSCC0.650.210.500.180.600.33proteinmRNASCNVmethylationLSCC0.720.020.610.150.740.23proteinmRNASCNVmethylationLUAD0.480.130.400.220.510.05proteinmRNASCNVmethylationOV0.090.300.45proteinmRNASCNVmethylationPDAC0.30-0.200.18-0.030.36-0.13proteinmRNASCNVmethylationUCEC0.34-0.080.210.100.330.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CNBP and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.