Basic information

Full name
collagen type IV alpha 2 chain
Ensembl
ENSG00000134871.19
Summary
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Annotation
Ligand

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.9e-6-3.7e-20--8.9e-19-1.2e-3-1.2e-7-0.49-
protein-4.5e-81--3.3e-26-3.9e-21-0.9-5.6e-32-1.3e-32-4.1e-100.048-1.1e-9

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC891011121314151617log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC232425262728293031log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer01020304050607080901001101201300-10-20-30-40-50-60-70-80-90-100-110-120-130proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of COL4A2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TGFb5.2e-461.2e-62.2e-162.4e-41.7e-41.2e-55.9e-93.5e-45.6e-61.7e-32.1e-3
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION2.1e-391.2e-61.2e-62.5e-45.2e-69.8e-61.9e-85.4e-33.2e-48.7e-51.1e-3
HALLMARK_ANGIOGENESIS7.6e-397.6e-66.8e-77.0e-58.7e-81.4e-56.5e-75.8e-42.8e-41.5e-40.023
HALLMARK_MYOGENESIS7.5e-382.1e-42.2e-161.0e-40.0131.2e-36.1e-70.0192.7e-43.8e-55.1e-5
HALLMARK_UV_RESPONSE_DN7.6e-381.4e-74.7e-81.4e-41.6e-31.6e-38.2e-93.8e-53.7e-68.6e-37.5e-3
xcell: Endothelial cell1.1e-365.8e-52.6e-80.0281.2e-81.2e-44e-71.8e-90.0320.0329.6e-4
xcell: stroma score1.3e-302.4e-42.2e-163.6e-49.6e-90.0538.8e-60.218.1e-40.0310.043
HALLMARK_TGF_BETA_SIGNALING3.4e-302.3e-41.5e-64.7e-44.1e-31.5e-32.7e-63.7e-69.4e-60.0360.026
HALLMARK_HYPOXIA1.6e-273.8e-60.31.9e-33.8e-50.0941.0e-61.4e-61.2e-31.5e-50.012
HALLMARK_APICAL_JUNCTION1.1e-262.8e-63.9e-60.0180.012.7e-53.9e-60.422.8e-56.3e-32.5e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of COL4A2

BRCA0.520.060.18proteinmRNASCNVmethylationCCRCC0.63-0.140.03-0.100.04-0.01proteinmRNASCNVmethylationCOAD0.24-0.090.04proteinmRNASCNVmethylationGBM0.630.010.040.020.04-0.05proteinmRNASCNVmethylationHNSCC0.52-0.130.07-0.430.17-0.09proteinmRNASCNVmethylationLSCC0.75-0.100.19-0.020.250.07proteinmRNASCNVmethylationLUAD0.49-0.000.150.14-0.030.11proteinmRNASCNVmethylationOV0.570.060.22proteinmRNASCNVmethylationPDAC0.61-0.160.04-0.040.210.12proteinmRNASCNVmethylationUCEC0.56-0.220.24-0.080.19-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of COL4A2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.