Gene: CRP

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
C-reactive protein
Ensembl
ENSG00000132693.12
Summary
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
Annotation
Ligand

Protein product

  • ENST00000255030.9 Primary ENSP00000255030.5 (0 phosphosite)
  • ENST00000368110.1
  • ENST00000368111.5
  • ENST00000368112.5
  • ENST00000437342.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA6.9e-3-0.026--7.5e-4-0.320.18-0.93-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CRP with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_TNFA_SIGNALING_VIA_NFKB-----------
HALLMARK_HYPOXIA-----------
HALLMARK_CHOLESTEROL_HOMEOSTASIS-----------
HALLMARK_MITOTIC_SPINDLE-----------
HALLMARK_WNT_BETA_CATENIN_SIGNALING-----------
HALLMARK_TGF_BETA_SIGNALING-----------
HALLMARK_IL6_JAK_STAT3_SIGNALING-----------
HALLMARK_DNA_REPAIR-----------
HALLMARK_G2M_CHECKPOINT-----------
HALLMARK_APOPTOSIS-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CRP

BRCA-0.13proteinmRNASCNVmethylationCCRCC0.12proteinmRNASCNVmethylationCOAD-0.17proteinmRNASCNVmethylationGBM0.09proteinmRNASCNVmethylationHNSCC-0.05proteinmRNASCNVmethylationLSCC-0.02proteinmRNASCNVmethylationLUAD-0.05proteinmRNASCNVmethylationOV-0.23proteinmRNASCNVmethylationPDAC-0.10proteinmRNASCNVmethylationUCEC-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CRP and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.