Basic information

Full name
cytochrome c1
Ensembl
ENSG00000179091.5
Summary
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.4e-9--2.9e-12---5.6e-57.7e-311.6e-27-0.07-
protein-0.031--1.7e-24-2.9e-5--3.3e-91.5e-201.1e-110.12-6.9e-30.72

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.52929.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of CYC1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_OXIDATIVE_PHOSPHORYLATION2.5e-173.7e-50.0240.48-0.881.9e-45.7e-61.9e-53.1e-32.4e-50.91
xcell: T cell CD4+ Th13.5e-90.0330.81-0.160.320.0282.5e-41.9e-50.287.2e-40.035
HALLMARK_MYC_TARGETS_V25.5e-74.3e-40.35-0.083-0.0140.23.0e-65.7e-50.0732.5e-40.89
HALLMARK_KRAS_SIGNALING_DN1.3e-60.0880.444.5e-39e-80.0291.8e-6-0.10.23-0.48-0.24
cibersort: T cell regulatory (Tregs)8.7e-60.410.0970.57-0.750.356.5e-40.0840.20.179.9e-3
Tumor Purity (WGS)1.0e-5--0.64-0.51-0.761.1e-56.4e-3-0.371.5e-4
chromosomal instability1.1e-40.066-0.0421.5e-30.28-0.21.2e-53.5e-40.370.56-0.98
HALLMARK_DNA_REPAIR1.4e-40.0210.19-0.17-1.4e-30.154.3e-42.5e-30.626.1e-40.28
HALLMARK_MYC_TARGETS_V12.5e-40.0570.14-0.55-0.020.0143.1e-43.1e-40.560.22-0.73
Tumor Purity (ABSOLUTE)7.4e-40.18-0.30.0590.7-0.482.6e-40.710.0580.828.1e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of CYC1

BRCA0.630.470.63proteinmRNASCNVmethylationCCRCC0.260.150.040.200.23-0.04proteinmRNASCNVmethylationCOAD0.350.510.48proteinmRNASCNVmethylationGBM0.30-0.040.150.050.44-0.03proteinmRNASCNVmethylationHNSCC0.40-0.010.09-0.190.56-0.16proteinmRNASCNVmethylationLSCC0.680.060.480.070.66-0.11proteinmRNASCNVmethylationLUAD0.57-0.020.460.020.65-0.02proteinmRNASCNVmethylationOV0.560.370.69proteinmRNASCNVmethylationPDAC0.50-0.170.13-0.190.320.02proteinmRNASCNVmethylationUCEC0.250.090.26-0.220.38-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of CYC1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.