Gene: DDR1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
discoidin domain receptor tyrosine kinase 1
Ensembl
ENSG00000204580.13
Summary
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Annotation
Druggable target (Tier T3) Protein Kinase Receptor

Protein product

  • ENST00000324771.12 Primary ENSP00000318217.8 (10 phosphosites)
  • ENST00000376568.7
  • ENST00000452441.5
  • ENST00000513240.5
  • ENST00000508312.5
  • ENST00000454612.6
  • ENST00000376567.6
  • ENST00000376570.8
  • ENST00000376569.7
  • ENST00000418800.6
  • ENST00000446312.5
  • ENST00000376575.7
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA9e-31--0.014--3.4e-54.2e-314.7e-27-0.086-
protein1.1e-8-0.19-0.076-0.253.6e-226.5e-30.72-0.61.1e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC56789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2121.52222.52323.52424.52525.526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DDR1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (WGS)9.6e-19--0.81-7.1e-55.9e-126.4e-80.045-0.022.3e-3
Tumor Purity (ABSOLUTE)4.5e-140.150.560.311.7e-42e-71.4e-60.410.0180.481.7e-3
chromosomal instability2.7e-110.240.160.990.65.4e-102.5e-90.160.0120.052-0.94
HALLMARK_GLYCOLYSIS2.8e-60.832.8e-30.14-0.0192.2e-35.2e-30.120.350.0380.042
PROGENy: VEGF7.7e-60.24-0.710.0270.0340.271.7e-30.74-0.952.3e-30.15
HALLMARK_DNA_REPAIR4.8e-50.63-0.38-0.54-0.189.4e-51.4e-50.10.148.6e-40.61
HALLMARK_SPERMATOGENESIS5.1e-50.22-0.75-0.445.9e-31.0e-43.1e-60.710.470.11-0.19
KINASE-PSP_ERK2/MAPK13.2e-4-0.810.13-0.78-0.144.4e-36.8e-70.03-0.40.510.039
HALLMARK_PEROXISOME3.3e-40.280.47-0.98-0.0220.0170.0920.0280.0130.180.074
HALLMARK_ESTROGEN_RESPONSE_LATE3.7e-40.0650.0244.6e-3-4.4e-40.390.0350.170.260.50.092
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DDR1

BRCA0.570.180.13proteinmRNASCNVmethylationCCRCC0.55-0.120.21-0.210.21-0.17proteinmRNASCNVmethylationCOAD0.29-0.050.48proteinmRNASCNVmethylationGBM0.77-0.120.12-0.130.20-0.07proteinmRNASCNVmethylationHNSCC0.74-0.230.29-0.170.28-0.34proteinmRNASCNVmethylationLSCC0.760.000.10-0.200.38-0.46proteinmRNASCNVmethylationLUAD0.65-0.040.310.100.47-0.05proteinmRNASCNVmethylationOV0.610.310.49proteinmRNASCNVmethylationPDAC0.46-0.060.210.050.36-0.25proteinmRNASCNVmethylationUCEC0.530.120.060.020.15-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DDR1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.