Gene: DMTF1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
cyclin D binding myb like transcription factor 1
Ensembl
ENSG00000135164.18
Summary
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Annotation
Transcription factor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.075-2.4e-16--3.5e-6-7.5e-4-7.8e-6--0.3-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCAGBMLSCCLUAD1414.51515.51616.51717.51818.51919.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910110-1-2-3-4-5-6-7-8-9-10-11Pan-cancer02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DMTF1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETS1.5e-40.48--4.7e-6--0.2---
HALLMARK_G2M_CHECKPOINT2.3e-40.67--1.4e-5--0.11---
KINASE-PSP_JNK1/MAPK82.3e-4---2.3e-4------
KINASE-PSP_CDK14.9e-40.1--5.9e-5--0.7---
KINASE-PSP_CDK22.7e-30.6--3.3e-5--0.61---
xcell: NK cell0.0030.17--0.016--0.17---
Tumor Purity (ABSOLUTE)3.7e-30.024--4.1e-3---0.92---
HALLMARK_MITOTIC_SPINDLE4.3e-3-0.95--6.3e-4--0.11---
PERT-PSP_NOCODAZOLE4.8e-30.12--5.4e-3--0.58---
PROGENy: PI3K6.3e-30.19--1.2e-3--0.85---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DMTF1

BRCA-0.41-0.440.42proteinmRNASCNVmethylationCCRCC-0.040.470.11proteinmRNASCNVmethylationCOAD0.36proteinmRNASCNVmethylationGBM0.320.060.17-0.120.710.09proteinmRNASCNVmethylationHNSCC-0.040.47-0.09proteinmRNASCNVmethylationLSCC0.200.370.10proteinmRNASCNVmethylationLUAD0.100.310.220.140.590.07proteinmRNASCNVmethylationOV0.39proteinmRNASCNVmethylationPDAC0.230.290.06proteinmRNASCNVmethylationUCEC-0.120.470.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DMTF1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.