Gene: DSC1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
desmocollin 1
Ensembl
ENSG00000134765.10
Summary
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015]
Annotation
Druggable target (Tier T5) Ligand

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.2e-16-0.11--1.6e-45.2e-267.3e-3--0.73-
protein-0.025--8.1e-25--3.7e-50.85----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCHNSCCLSCCLUADOVUCEC1415161718192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.00.0-0.5-1.0-1.5-2.0-2.5-3.0-3.5-4.0-4.5-5.0-5.5-6.0-6.5-7.0proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DSC1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_APICAL_SURFACE2.4e-79.2e-40.014--0.0240.02-0.24-0.27
PROGENy: p532.8e-70.0230.4--2.7e-91.4e-3-0.97-0.78
HALLMARK_P53_PATHWAY3e-70.040.035--3.0e-60.013--0.41-0.04
PROGENy: EGFR3.5e-70.261.2e-3--8.8e-50.065-0.86-0.029
HALLMARK_TNFA_SIGNALING_VIA_NFKB7.6e-60.0660.041--7.4e-40.63-0.89-0.002
PROGENy: MAPK8.9e-60.231.4e-4--0.0330.072-0.56-0.18
HALLMARK_APICAL_JUNCTION9.3e-60.0158.4e-3--0.715.6e-4-0.14-0.62
PROGENy: VEGF1.0e-5-0.840.024--6.6e-72.7e-3--0.49-0.14
xcell: Endothelial cell2.8e-50.0760.009--6.1e-30.26-0.046-1
PROGENy: TNFa2.8e-50.320.2--0.0620.66-0.38-1.6e-6
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DSC1

BRCA0.07-0.120.05proteinmRNASCNVmethylationCCRCC-0.130.050.17proteinmRNASCNVmethylationCOAD-0.03proteinmRNASCNVmethylationGBM-0.19proteinmRNASCNVmethylationHNSCC0.860.04-0.02proteinmRNASCNVmethylationLSCC0.600.040.21proteinmRNASCNVmethylationLUAD0.22proteinmRNASCNVmethylationOV0.100.210.24proteinmRNASCNVmethylationPDAC0.37proteinmRNASCNVmethylationUCEC-0.100.220.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DSC1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.