Gene: DTNA

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
dystrobrevin alpha
Ensembl
ENSG00000134769.21
Summary
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000444659.5 Primary ENSP00000405819.1 (32 phosphosites)
  • ENST00000399113.7
  • ENST00000556414.7
  • ENST00000591182.5
  • ENST00000315456.10
  • ENST00000554864.7
  • ENST00000601125.5
  • ENST00000596745.5
  • ENST00000597674.5
  • ENST00000590831.2
  • ENST00000599844.5
  • ENST00000598334.5
  • ENST00000399121.9
  • ENST00000283365.13
  • ENST00000598142.5
  • ENST00000595022.5
  • ENST00000348997.9
  • ENST00000598774.5
  • ENST00000597599.5
  • ENST00000269192.11
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.8e-30--0.24---3.5e-4-3.2e-16-3.6e-11--9e-10-
protein-6.4e-81--7.0e-4-4.6e-29--4.3e-4-8e-35-2.4e-28--3.1e-12-0.048

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC345678910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC141618202224262830log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025300-5-10-15-20-25-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DTNA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYOGENESIS1.6e-320.0730.0435.7e-74.5e-32.2e-164.9e-62.9e-3-0.0351.1e-9
xcell: Hematopoietic stem cell1.2e-200.12-0.93.7e-70.0349.4e-41.5e-61.9e-6-1.2e-31.5e-3
xcell: Cancer associated fibroblast3.2e-180.0220.0231.3e-9-0.461.8e-49.1e-41.7e-3-0.0339.3e-5
ESTIMATE: StromalScore2.6e-170.0370.247.5e-5-0.722.6e-70.0230.23-0.0892.2e-16
xcell: stroma score2.9e-160.023-0.539.1e-9-0.872.9e-57.1e-50.002-0.0396.5e-5
KINASE-PSP_PKCA/PRKCA1.6e-140.024-8.5e-38.5e-45.2e-46.6e-43.3e-5-0.150.31
HALLMARK_APICAL_JUNCTION2.3e-130.0160.0230.0410.653.7e-70.120.021-0.462.9e-7
HALLMARK_UV_RESPONSE_DN2.8e-130.0490.447.4e-40.0410.0130.019.3e-3-0.0662.0e-5
ESTIMATE: ESTIMATEScore1.5e-100.30.391.2e-3-0.62.7e-50.0260.089-0.164.1e-7
HALLMARK_KRAS_SIGNALING_UP1.6e-100.0570.189.8e-6-0.780.0110.0140.082-0.343.5e-5
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DTNA

BRCA0.78-0.07-0.12proteinmRNASCNVmethylationCCRCC0.82-0.02-0.13-0.040.03-0.20proteinmRNASCNVmethylationCOAD0.57-0.09-0.11proteinmRNASCNVmethylationGBM0.75-0.230.14-0.340.250.06proteinmRNASCNVmethylationHNSCC0.600.140.04-0.250.17-0.04proteinmRNASCNVmethylationLSCC0.79-0.010.01-0.210.19-0.08proteinmRNASCNVmethylationLUAD0.54-0.010.12-0.330.120.06proteinmRNASCNVmethylationOV0.18proteinmRNASCNVmethylationPDAC0.56-0.170.25-0.090.270.09proteinmRNASCNVmethylationUCEC0.59-0.270.14-0.510.04-0.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DTNA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.