Gene: DYRK3

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
dual specificity tyrosine phosphorylation regulated kinase 3
Ensembl
ENSG00000143479.17
Summary
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Annotation
IDG target Druggable target (Tier T4) Protein Kinase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.072-1.1e-17--6.6e-16-1.8e-10-0.014--6.2e-4-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC66.577.588.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer024681012141618200-2-4-6-8-10-12-14-16-18-20proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of DYRK3 with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: T cell CD8+ effector memory-----------
HALLMARK_HEDGEHOG_SIGNALING-----------
SETD1B mutation-----------
NOTCH1 mutation-----------
ZFP36L2 mutation-----------
UPF3A mutation-----------
ZNF540 mutation-----------
PTX4 mutation-----------
ATRX mutation-----------
SBS42 (haloalkane exposure)-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of DYRK3

BRCA0.29proteinmRNASCNVmethylationCCRCC0.090.11-0.16proteinmRNASCNVmethylationCOAD0.11proteinmRNASCNVmethylationGBM-0.100.37-0.10proteinmRNASCNVmethylationHNSCC-0.080.11-0.20proteinmRNASCNVmethylationLSCC-0.120.22-0.19proteinmRNASCNVmethylationLUAD0.160.300.14proteinmRNASCNVmethylationOV0.45proteinmRNASCNVmethylationPDAC-0.030.240.02proteinmRNASCNVmethylationUCEC-0.270.41-0.39proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of DYRK3 and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.