Basic information
- Full name
- E4F transcription factor 1
- Ensembl
- ENSG00000167967.16
- Summary
- The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
- Annotation
- Transcription factor
Protein product
- ENST00000301727.9 Primary ENSP00000301727.4 (10 phosphosites)
- ENST00000564139.5
- ENST00000565090.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 3.4e-22 | - | 8.2e-6 | - | - | 0.14 | 6.2e-11 | 1.8e-17 | - | 0.5 | - |
protein | 0.05 | - | 0.31 | - | - | -1.2e-3 | 9.5e-9 | 0.013 | - | - | -0.11 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of E4F1 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_JNK1/MAPK8 | 9.0e-4 | - | - | - | 0.01 | - | - | - | - | - | 0.034 | |
xcell: T cell CD8+ naive | 3.6e-3 | 0.68 | 0.025 | - | 0.38 | 0.64 | -0.96 | 0.038 | 0.62 | -0.76 | 0.012 | |
xcell: T cell CD8+ effector memory | 5.9e-3 | 0.18 | 0.31 | - | 0.016 | 0.016 | -0.64 | 0.4 | -0.52 | 0.89 | 0.23 | |
xcell: T cell CD4+ Th2 | 9.5e-3 | -0.15 | 0.54 | - | 0.059 | 0.86 | 0.86 | 0.01 | 0.78 | 0.069 | 0.087 | |
HALLMARK_DNA_REPAIR | 0.011 | 0.41 | -0.54 | - | 0.093 | -0.74 | 0.033 | 0.55 | 0.42 | 0.44 | 0.071 | |
SBS31 (platinum chemotherapy) | 0.012 | - | - | - | 0.012 | - | - | - | - | - | - | |
xcell: B cell | 0.013 | 0.37 | 0.46 | - | 0.24 | 0.27 | -0.034 | 0.02 | 0.29 | 0.35 | 0.18 | |
xcell: Class-switched memory B cell | 0.016 | 0.099 | 0.17 | - | 0.31 | 0.11 | -0.025 | 0.24 | 0.8 | 0.16 | 0.32 | |
xcell: T cell NK | 0.026 | 0.045 | 0.95 | - | -0.99 | 0.21 | -0.59 | 0.2 | -0.7 | 0.04 | 0.34 | |
xcell: T cell gamma delta | 0.036 | 2.6e-3 | 0.68 | - | 0.1 | 0.094 | 0.89 | -0.4 | -0.41 | 0.29 | 0.99 |
Cis-association
Associations between omics data of E4F1
Trans-association
Associations of the protein abundance of E4F1 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.