Basic information
- Full name
- Era like 12S mitochondrial rRNA chaperone 1
- Ensembl
- ENSG00000132591.12
- Summary
- The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Protein product
- ENST00000254928.10 Primary ENSP00000254928.5 (2 phosphosites)
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 2.7e-22 | - | -1.4e-22 | - | - | 5e-10 | 7.1e-28 | 4.3e-28 | - | 0.077 | - |
protein | 8.0e-5 | - | -1.9e-23 | 2.7e-9 | - | -0.55 | 5.4e-16 | 3.3e-13 | 0.22 | -4.8e-7 | 0.015 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of ERAL1 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_MYC_TARGETS_V2 | 2.5e-31 | 6.6e-6 | 9.1e-3 | 0.17 | 0.92 | 6.7e-9 | 9.9e-9 | 1.8e-5 | 0.021 | 0.059 | 2.2e-16 | |
chromosomal instability | 4.9e-27 | 4.3e-3 | 0.012 | 2.2e-16 | 1.1e-3 | 1.2e-4 | 2.5e-7 | 1.1e-5 | 1.4e-4 | -0.58 | 0.58 | |
KINASE-PSP_CDK2 | 5.3e-22 | 4.6e-4 | 4.1e-3 | 0.22 | 0.48 | 4.6e-3 | 5.4e-7 | 5.1e-4 | 0.046 | 0.004 | 2e-9 | |
HALLMARK_E2F_TARGETS | 1.2e-21 | 2.1e-3 | 0.042 | 1 | 0.3 | 2.4e-3 | 1.5e-5 | 2.6e-4 | 0.13 | 0.071 | 2.2e-16 | |
HALLMARK_MYC_TARGETS_V1 | 1.6e-17 | 0.042 | 0.037 | 0.037 | 0.65 | 0.001 | 1.1e-6 | 2.0e-5 | 0.68 | 0.06 | 2.7e-8 | |
HALLMARK_G2M_CHECKPOINT | 8e-16 | 0.015 | 8.2e-3 | -0.51 | 0.4 | 7.6e-5 | 1.4e-5 | 2.5e-4 | 0.66 | 0.087 | 1.1e-9 | |
HALLMARK_DNA_REPAIR | 1.5e-15 | 6.5e-3 | 0.46 | 0.68 | 0.8 | 0.028 | 6.8e-5 | 2.8e-5 | 0.12 | 0.32 | 2.2e-16 | |
PERT-PSP_NOCODAZOLE | 2e-15 | 1.7e-3 | 0.017 | 0.11 | -0.77 | 1.2e-3 | 3.9e-7 | 2.2e-4 | 0.15 | 0.19 | 3.8e-4 | |
xcell: T cell CD4+ Th1 | 2.3e-15 | 1.1e-3 | 0.75 | 0.75 | 0.017 | 1.8e-3 | 3.9e-5 | 3.8e-7 | 0.61 | 0.75 | 1.7e-8 | |
KINASE-PSP_CK2A1/CSNK2A1 | 6.5e-15 | 0.03 | 0.012 | 0.2 | 0.018 | 1.7e-3 | 0.003 | 5.9e-4 | -0.77 | 4.2e-3 | 2.8e-5 |
Cis-association
Associations between omics data of ERAL1
Trans-association
Associations of the protein abundance of ERAL1 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.