Gene: EYA4

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
EYA transcriptional coactivator and phosphatase 4
Ensembl
ENSG00000112319.19
Summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Annotation
Phosphatase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.2e-32--5.6e-28--0.23-2.9e-15-1.7e-23-0.3-
protein-0.029------0.029----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213log2(RSEM+1)tumornormal
Protein expression
GBMHNSCCLSCCLUADOVUCEC11121314151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112130-1-2-3-4-5-6-7-8-9-10-11-12-13Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of EYA4 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_PLK16.5e-3---6.6e-3------
PROGENy: WNT0.01---0.24-0.280.180.13--
PROGENy: VEGF0.058---0.12--0.88-0.664.4e-3--
cibersort: T cell gamma delta0.094---0.028-0.320.4-0.5--
Clinical: Age0.12----0.44-0.064-0.890.033--
HALLMARK_NOTCH_SIGNALING0.13----0.89--0.970.981.6e-3--
EGFR mutation0.14---0.14------
cibersort: Macrophage M00.18---0.61-0.840.470.22--
HALLMARK_ANGIOGENESIS0.18---0.25-0.750.270.92--
cibersort: NK cell activated0.19---0.43-0.57-0.740.1--
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of EYA4

BRCA-0.10proteinmRNASCNVmethylationCCRCC-0.220.08-0.09proteinmRNASCNVmethylationCOAD-0.22proteinmRNASCNVmethylationGBM0.67-0.230.15-0.240.00-0.17proteinmRNASCNVmethylationHNSCC-0.460.15-0.10proteinmRNASCNVmethylationLSCC0.520.030.27-0.130.040.19proteinmRNASCNVmethylationLUAD0.47-0.420.28-0.340.25-0.05proteinmRNASCNVmethylationOV0.87-0.01-0.08proteinmRNASCNVmethylationPDAC-0.090.24-0.12proteinmRNASCNVmethylationUCEC-0.33-0.080.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of EYA4 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.