Basic information

Full name
fatty acid desaturase 1
Ensembl
ENSG00000149485.19
Summary
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T2)

Protein product

  • ENST00000350997.12 Primary ENSP00000322229.9 (0 phosphosite)
  • ENST00000542506.5
  • ENST00000433932.5
  • ENST00000536991.5
  • ENST00000460649.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA8.3e-17-1.3e-17--4.2e-170.570.069--0.48-
protein3.3e-5-5.3e-4--1.4e-70.0220.40.94-0.0190.16

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC67891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC16.51717.51818.51919.52020.52121.52222.52323.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer024681012140-2-4-6-8-10-12-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of FADS1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETS5.6e-120.890.46-9.4e-30.0128.0e-43.9e-45.9e-30.732.8e-6
HALLMARK_G2M_CHECKPOINT3.6e-11-0.910.37-0.0130.0188.4e-53.9e-41.1e-3-0.66.2e-5
HALLMARK_SPERMATOGENESIS7.3e-110.0820.48-0.0184.4e-32.8e-37.6e-43.3e-3-0.51.1e-3
KINASE-PSP_CDK23.4e-90.0540.64-2.8e-32.1e-30.0193.2e-30.029-0.940.061
KINASE-PSP_CDK11.8e-80.340.68-3.3e-30.0032.3e-47.5e-30.0140.620.77
xcell: T cell CD4+ Th13.6e-7-0.720.26-9.1e-3-0.850.0666.8e-30.0230.62.1e-6
HALLMARK_DNA_REPAIR5.6e-60.510.15-0.380.0260.0160.450.31-0.951.6e-5
HALLMARK_MITOTIC_SPINDLE9.0e-6-0.49-0.38-0.0350.493.8e-45.7e-31.6e-30.530.049
Tumor Purity (ABSOLUTE)9.3e-60.280.096-1.0e-40.0460.0360.10.61-0.0840.032
PERT-PSP_NOCODAZOLE1.2e-50.470.74-0.385.3e-33.8e-30.0370.0330.820.29
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of FADS1

BRCA0.450.090.19proteinmRNASCNVmethylationCCRCC-0.23-0.110.12-0.030.010.01proteinmRNASCNVmethylationCOAD0.09proteinmRNASCNVmethylationGBM0.72-0.130.23-0.200.21-0.04proteinmRNASCNVmethylationHNSCC0.58-0.180.11-0.340.26-0.07proteinmRNASCNVmethylationLSCC0.81-0.330.16-0.170.180.03proteinmRNASCNVmethylationLUAD0.71-0.090.19-0.150.33-0.15proteinmRNASCNVmethylationOV0.69-0.20-0.14proteinmRNASCNVmethylationPDAC-0.06-0.250.27-0.330.060.07proteinmRNASCNVmethylationUCEC0.68-0.160.33-0.090.31-0.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of FADS1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.