Basic information

Full name
Fc fragment of IgE receptor Ia
Ensembl
ENSG00000179639.10
Summary
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Annotation
Druggable target (Tier T2) Receptor

Protein product

  • ENST00000368115.5 Primary ENSP00000357097.1 (0 phosphosite)
  • ENST00000368114.1
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-7.5e-54--2.6e-3---9.3e-20-5.6e-31-2.9e-12--1.0e-4-
protein-5.6e-13------4.9e-11-2.9e-4---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011log2(RSEM+1)tumornormal
Protein expression
LSCCLUADPDAC14.51515.51616.51717.51818.51919.520log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025303540455055600-5-10-15-20-25-30-35-40-45-50-55-60proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of FCER1A with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Mast cell4.1e-5-----8.3e-40.014---
ESTIMATE: StromalScore1.7e-4-----1.5e-30.031---
xcell: microenvironment score2.5e-4-----1.5e-30.046---
ESTIMATE: ESTIMATEScore3.0e-4-----1.1e-30.066---
xcell: Monocyte3.5e-4-----1.4e-40.21---
KINASE-PSP_PKCA/PRKCA4.2e-4-----0.0030.043---
HALLMARK_MYOGENESIS4.7e-4-----1.5e-30.076---
xcell: Macrophage M25.6e-4-----4.3e-50.43---
KINASE-PSP_PKACA/PRKACA6.0e-4-----0.0140.017---
xcell: immune score6.9e-4-----1.2e-30.12---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of FCER1A

BRCA-0.15proteinmRNASCNVmethylationCCRCC0.03proteinmRNASCNVmethylationCOAD-0.00proteinmRNASCNVmethylationGBM0.17proteinmRNASCNVmethylationHNSCC-0.15proteinmRNASCNVmethylationLSCC0.52-0.10-0.32proteinmRNASCNVmethylationLUAD0.240.24-0.12proteinmRNASCNVmethylationOV-0.05proteinmRNASCNVmethylationPDAC-0.05proteinmRNASCNVmethylationUCEC-0.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of FCER1A and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.