Basic information

Full name
fms related receptor tyrosine kinase 1
Ensembl
ENSG00000102755.12
Summary
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Annotation
Druggable target (Tier T1) Protein Kinase Receptor

Protein product

  • ENST00000282397.9 Primary ENSP00000282397.4 (6 phosphosites)
  • ENST00000541932.5
  • ENST00000615840.4
  • ENST00000639477.1
  • ENST00000539099.1
  • ENST00000615611.4
  • ENST00000543394.2
  • ENST00000540678.2
  • ENST00000617835.4
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.19-1.8e-25--2.5e-5-3.5e-19-1.7e-16-0.26-
protein2.5e-29-1.4e-230.025-5.8e-61.3e-132.6e-5-0.0280.0064.2e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC678910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC17181920212223242526272829log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30Pan-cancer010203040506070800-10-20-30-40-50-60-70-80proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of FLT1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: Hypoxia2.1e-391.6e-80.260.132e-82.1e-41.5e-84.8e-106.2e-62.4e-59.5e-4
HALLMARK_HYPOXIA6.1e-281.4e-40.150.262.5e-63.5e-34.6e-53.5e-74.8e-31.7e-51.5e-5
HALLMARK_ANGIOGENESIS3.2e-227.4e-33.8e-30.0861.2e-90.0441.2e-39.1e-50.082.5e-38.7e-4
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION5.4e-228.7e-40.030.282.6e-70.0181.3e-33.1e-42.6e-36.0e-41.7e-3
PROGENy: TGFb8.6e-210.0145.1e-50.172.5e-60.0690.0156.7e-34.9e-44.7e-50.013
xcell: Endothelial cell3.3e-160.0712.2e-160.492.5e-9-0.420.251.4e-30.280.531.0e-4
HALLMARK_UV_RESPONSE_DN4.5e-130.0141.2e-40.616.8e-40.320.160.591.1e-32.3e-50.024
HALLMARK_TGF_BETA_SIGNALING1e-120.135.3e-70.131.9e-30.720.0850.167.4e-42.9e-30.13
HALLMARK_GLYCOLYSIS1.2e-111.2e-5-9.3e-3-0.937.9e-82.6e-51.5e-58.7e-3-0.910.0610.14
HALLMARK_APICAL_JUNCTION2.5e-100.0730.0350.767.0e-40.118.3e-3-0.353.4e-35.8e-40.006
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of FLT1

BRCA0.420.010.15proteinmRNASCNVmethylationCCRCC0.67-0.220.19-0.230.04-0.01proteinmRNASCNVmethylationCOAD0.23-0.200.10proteinmRNASCNVmethylationGBM0.800.150.020.14-0.050.05proteinmRNASCNVmethylationHNSCC0.44-0.300.01-0.150.06-0.04proteinmRNASCNVmethylationLSCC0.61-0.08-0.050.110.080.20proteinmRNASCNVmethylationLUAD0.690.15-0.140.17-0.00-0.03proteinmRNASCNVmethylationOV0.560.000.23proteinmRNASCNVmethylationPDAC0.680.200.180.170.100.01proteinmRNASCNVmethylationUCEC0.610.04-0.020.140.10-0.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of FLT1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.