Gene: FRK

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
fyn related Src family tyrosine kinase
Ensembl
ENSG00000111816.8
Summary
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T1) Protein Kinase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA9.6e-4--7.2e-25---0.523.8e-126.2e-20-0.88-
protein9.5e-6--8.5e-210.06--3.8e-31.5e-141.6e-130.744.8e-44.2e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC34567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADHNSCCLSCCLUADOVPDACUCEC19.52020.52121.52222.52323.52424.525log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer024681012140-2-4-6-8-10-12-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of FRK with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
chromosomal instability3.5e-130.720.160.85-3.6e-65.3e-60.0194.5e-41.0e-50.68
Tumor Purity (WGS)6.2e-12-0.091--3.2e-53.7e-50.028-9.7e-50.44
HALLMARK_GLYCOLYSIS5e-90.0861.1e-3-0.82-0.0390.0210.0370.160.22.9e-4
mutation burden1.4e-60.680.330.32-0.164.2e-3-0.830.0180.0170.001
Tumor Purity (ABSOLUTE)2.7e-6-0.40.027-0.88-1.3e-35.3e-50.210.17.9e-30.97
KINASE-PSP_ERK2/MAPK18.7e-6-0.670.083-0.96-0.711.5e-56.2e-40.620.722.1e-3
PERT-PSP_NOCODAZOLE1.8e-50.240.19-0.32-0.0270.0149.8e-30.11-0.73.6e-3
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY2.8e-40.470.190.32-0.176.6e-3-0.50.44-0.756.3e-5
HALLMARK_E2F_TARGETS2.8e-40.260.450.4-0.325.5e-30.770.190.140.18
HALLMARK_FATTY_ACID_METABOLISM4.5e-4-0.171.5e-41-8.3e-36.9e-3-0.970.250.730.2
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of FRK

BRCA0.620.050.06proteinmRNASCNVmethylationCCRCC0.620.150.23proteinmRNASCNVmethylationCOAD0.050.050.21proteinmRNASCNVmethylationGBM0.14proteinmRNASCNVmethylationHNSCC0.700.210.30proteinmRNASCNVmethylationLSCC0.590.030.36proteinmRNASCNVmethylationLUAD0.600.290.44proteinmRNASCNVmethylationOV0.600.600.45proteinmRNASCNVmethylationPDAC0.540.200.61proteinmRNASCNVmethylationUCEC0.660.140.20proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of FRK and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.