Basic information

Full name
follistatin
Ensembl
ENSG00000134363.12
Summary
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Annotation
Ligand

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.5e-4--3.5e-9--3.2e-171.6e-20-1.2e-7-0.19-
protein9e-21----1.4e-121.2e-19-0.79-5.1e-3-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC15161718192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer05101520253035404550550-5-10-15-20-25-30-35-40-45-50-55proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of FST with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION8.9e-161.4e-100.03-0.0122.8e-30.142.3e-30.411.2e-30.14
PROGENy: TGFb4.6e-152.2e-160.052-0.0160.230.341.6e-40.283.4e-30.31
HALLMARK_MYOGENESIS7e-111.2e-100.032-0.120.620.549.1e-30.0858.6e-30.17
ESTIMATE: StromalScore1.1e-94.7e-90.026-4.1e-30.67-0.257.3e-30.436.3e-40.25
HALLMARK_ANGIOGENESIS1.7e-93.1e-120.03-0.0170.021-0.887.0e-40.63-0.590.3
HALLMARK_UV_RESPONSE_DN2e-91.6e-102.7e-3-0.130.790.860.210.240.0440.028
HALLMARK_APICAL_JUNCTION5.3e-82.9e-60.022-0.130.460.230.360.0960.0450.19
HALLMARK_HEDGEHOG_SIGNALING6.5e-87.6e-50.059-0.170.451.7e-40.30.10.310.43
HALLMARK_HYPOXIA1.3e-78.6e-40.052-0.198.9e-30.260.120.350.0420.33
HALLMARK_TGF_BETA_SIGNALING1.6e-73.7e-80.099-0.110.0540.830.560.230.080.2
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of FST

BRCA0.780.150.03proteinmRNASCNVmethylationCCRCC0.52-0.47-0.30-0.180.04-0.11proteinmRNASCNVmethylationCOAD-0.00proteinmRNASCNVmethylationGBM0.50-0.110.25-0.140.06-0.23proteinmRNASCNVmethylationHNSCC0.81-0.220.10-0.070.12-0.40proteinmRNASCNVmethylationLSCC0.90-0.28-0.04-0.250.00-0.24proteinmRNASCNVmethylationLUAD0.66-0.15-0.31-0.10-0.07-0.01proteinmRNASCNVmethylationOV0.630.070.13proteinmRNASCNVmethylationPDAC0.670.000.07-0.040.04-0.11proteinmRNASCNVmethylationUCEC0.25-0.050.32-0.030.07-0.20proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of FST and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.