Gene: GAD2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
glutamate decarboxylase 2
Ensembl
ENSG00000136750.13
Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Protein product

  • ENST00000376261.8 Primary ENSP00000365437.3 (0 phosphosite)
  • ENST00000259271.7
  • ENST00000648567.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.1e-3-9.7e-13--0.223.4e-30.38--1.3e-6-
protein-2.4e-6---------2.4e-6-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112log2(RSEM+1)tumornormal
Protein expression
GBMPDAC19202122232425262728log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025303540450-5-10-15-20-25-30-35-40-45Pan-cancer0246810121416180-2-4-6-8-10-12-14-16-18proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GAD2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_PANCREAS_BETA_CELLS1e-19---2.2e-16----3.4e-6-
HALLMARK_KRAS_SIGNALING_DN2.1e-8---2.6e-8----0.018-
HALLMARK_SPERMATOGENESIS3.2e-7---2.6e-6----0.012-
DISEASE-PSP_Alzheimer's_disease2.6e-5---2.6e-5------
HALLMARK_HEDGEHOG_SIGNALING8.4e-4---1.9e-5----0.66-
xcell: Hematopoietic stem cell1.5e-3---8.1e-3----0.066-
PROGENy: Estrogen3.1e-3---0.43----6.9e-4-
Clinical: Age7.5e-3---0.015----0.18-
SMAD4 mutation0.022--------0.022-
xcell: B cell plasma0.038---5.8e-3----0.86-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GAD2

BRCA0.01proteinmRNASCNVmethylationCCRCC-0.080.060.03proteinmRNASCNVmethylationCOAD-0.08proteinmRNASCNVmethylationGBM0.83-0.02-0.04-0.01-0.06-0.40proteinmRNASCNVmethylationHNSCC-0.040.120.10proteinmRNASCNVmethylationLSCC-0.06-0.020.09proteinmRNASCNVmethylationLUAD0.150.140.23proteinmRNASCNVmethylationOV-0.03proteinmRNASCNVmethylationPDAC0.48-0.10-0.140.11-0.010.19proteinmRNASCNVmethylationUCEC-0.17-0.150.24proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GAD2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.